评估天疱疮和类天疱疮患者的干眼严重程度和眼表炎症。
Evaluation of Dry Eye Severity and Ocular Surface Inflammation in Patients with Pemphigus and Pemphigoid.
机构信息
Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China.
出版信息
Ocul Immunol Inflamm. 2024 Jan;32(1):62-70. doi: 10.1080/09273948.2022.2154680. Epub 2023 Jan 13.
PURPOSE
To evaluate ocular surface involvement, tear cytokine levels, and histopathological changes in pemphigus and pemphigoid patients.
METHODS
A total of 22 patients (15 pemphigus and 7 pemphigoids) and 21 non-diseased controls were enrolled in our study. All participants underwent ocular surface evaluation, which included ocular surface disease index test, slit lamp observation, dry eye-related examination, tear multicytokine analysis, and conjunctival impression cytology.
RESULTS
Pemphigus and pemphigoid patients presented much more severe conjunctivochalasis, corneal epithelial defects, corneal opacity, symblepharon and dry eye. Severe ocular surface squamous metaplasia and a significant increase of tear macrophage inflammatory protein-1beta, tumor necrosis factor-alpha, interleukin (IL)-1β, IL -6, and IL-8 occurred in pemphigus and pemphigoid patients.
CONCLUSIONS
Our results revealed that ocular surface inflammation and dry eye persist in most pemphigus and pemphigoid patients, and do not occur in parallel with the systemic course. Regular ophthalmological examinations and local anti-inflammatory should be provided for pemphigus and pemphigoid patients.
目的
评估天疱疮和类天疱疮患者的眼表受累、泪液细胞因子水平和组织病理学变化。
方法
本研究共纳入 22 例患者（15 例天疱疮和 7 例类天疱疮）和 21 名非疾病对照者。所有参与者均接受了眼表评估，包括眼表疾病指数测试、裂隙灯观察、干眼症相关检查、泪液多细胞因子分析和结膜印迹细胞学检查。
结果
天疱疮和类天疱疮患者的结膜松弛、角膜上皮缺损、角膜混浊、睑球粘连和干眼症更为严重。天疱疮和类天疱疮患者的眼表鳞状上皮化生严重，且泪液巨噬细胞炎症蛋白-1β、肿瘤坏死因子-α、白细胞介素（IL）-1β、IL-6 和 IL-8 显著增加。
结论
我们的研究结果表明，大多数天疱疮和类天疱疮患者存在眼表炎症和干眼症，且与系统性病程不同步。应定期对天疱疮和类天疱疮患者进行眼科检查和局部抗炎治疗。
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