Holland S J, Jolly A M, Yasin M, Tighe B J
Department of Molecular Sciences, Aston University, Birmingham, UK.
Biomaterials. 1987 Jul;8(4):289-95. doi: 10.1016/0142-9612(87)90117-7.
The hydrolytic degradation of poly(hydroxybutyrate) together with a series of hydroxybutyrate-hydroxyvalerate copolymers has been studied. The effects of copolymer composition and molecular weight are presented together with the results of varying pH and temperature on the degradation rate. Degradation has been monitored by weight loss and water uptake measurements together with goniophotometric, surface energy and scanning electron microscopic studies. Some comparisons with the more widely used so-called 'biodegradable' polymers, poly(glycolic acid), poly(dioxanone) and the glycolic-lactic acid (90:10) copolymers are presented together with the effect of blood plasma on the degradation process.
对聚羟基丁酸酯以及一系列羟基丁酸酯-羟基戊酸酯共聚物的水解降解进行了研究。给出了共聚物组成和分子量的影响，以及不同pH值和温度对降解速率的影响结果。通过重量损失和吸水率测量以及测角光度法、表面能和扫描电子显微镜研究对降解进行了监测。还给出了与使用更广泛的所谓“可生物降解”聚合物聚乙醇酸、聚二氧杂环己酮和乙醇酸-乳酸（90:10）共聚物的一些比较，以及血浆对降解过程的影响。
