Miller N D, Williams D F
Biomaterials. 1987 Mar;8(2):129-37. doi: 10.1016/0142-9612(87)90102-5.
The known biodegradability of PHB in certain biological environments has led to its proposed use as a 'biodegradable' implant material. Monofilaments of PHB homopolymer and two PHV-PHB copolymers have been studied in vivo and in vitro and assessed for changes in mechanical properties and topography. In vivo biodegradation was only observed with PHB when pre-degraded by 10.0 Mrad of gamma-irradiation before implantation. High temperature in vitro hydrolysis suggested that PHV copolymer additions retarded the rate of degradation of PHB. Hydration reactions had most effect on the ultimate tensile properties of the materials. In contrast, the elastic properties appeared to be relatively unaffected.
聚羟基丁酸酯（PHB）在某些生物环境中已知的生物降解性，使其被提议用作“可生物降解”的植入材料。已对PHB均聚物和两种聚羟基戊酸酯-聚羟基丁酸酯（PHV-PHB）共聚物的单丝进行了体内和体外研究，并评估了其机械性能和表面形貌的变化。仅当PHB在植入前经10.0兆拉德的γ射线预降解时，才在体内观察到生物降解。高温体外水解表明，添加PHV共聚物会延缓PHB的降解速率。水合反应对材料的极限拉伸性能影响最大。相比之下，弹性性能似乎相对未受影响。
