一种兼具聚氨酯特性和大量吸附肝素能力的材料（PUPA）。

A material (PUPA) presenting both the properties of polyurethanes and the capacity of adsorbing a high quantity of heparin.

作者信息

Barbucci R, Benvenuti M, Dal Maso G, Ferruti P, Tempesti F, Lemm W G

机构信息

C.R.I.S.M.A. Centro Didattico Università di Siena, Italy.

出版信息

Biomaterials. 1987 Jul;8(4):306-7. doi: 10.1016/0142-9612(87)90120-7.

DOI:10.1016/0142-9612(87)90120-7

PMID:3663808

Abstract

Polyurethanes are widely used for biomedical applications, but there is still a constant search for improved blood-compatible materials. We studied a material (PUPA) obtained by the interconnection between a poly(amido-amine), N2LL, capable of forming stable complexes with heparin and a commercial polyurethane, Pellethane 2363-80AE, using hexamethylenediisocyanate as the crosslinking agent. The amount of absorbed heparin (evaluated by biological tests) was generally much higher than that found on the poly(amido-amine) surface-grafted polyurethane.

摘要

聚氨酯被广泛应用于生物医学领域，但人们仍在不断寻找性能更优的血液相容性材料。我们研究了一种材料（PUPA），它是通过一种能够与肝素形成稳定复合物的聚（酰胺 - 胺）N2LL和一种商用聚氨酯Pellethane 2363 - 80AE之间相互连接而得到的，使用六亚甲基二异氰酸酯作为交联剂。通过生物学测试评估发现，该材料吸收的肝素量通常比表面接枝聚氨酯的聚（酰胺 - 胺）上的肝素量高得多。