Terheggen H G, Rado M
Monatsschr Kinderheilkd (1902). 1978 Dec;126(12):693-5.
Prophylactic irradiation of the skull and intrathecal application of methotrexate has proven to be highly effective in preventing central nervous system disease in acute lymphoblastic leukemia or non-Hodgkin-lymphoma. Prophylactic treatment may be complicated by a somnolence syndrome occuring 4--8 weaks after the end of irradiation. The main features of this clinical entity are somnolence, lethargy, dullness, anorexia, headache, and vomiting. EEG frequently displays a distinct slowing of activity. All symptoms are reversible after 3--49 days. The syndrome clearly is consequence of skull irradiation. Its metabolic basis probably is transient disturbance of myelinization.
对头骨进行预防性照射以及鞘内注射甲氨蝶呤已被证明在预防急性淋巴细胞白血病或非霍奇金淋巴瘤的中枢神经系统疾病方面非常有效。预防性治疗可能会因在照射结束后4 - 8周出现的嗜睡综合征而变得复杂。这一临床病症的主要特征为嗜睡、倦怠、迟钝、厌食、头痛和呕吐。脑电图常显示活动明显减慢。所有症状在3 - 49天后均可逆转。该综合征显然是头骨照射的结果。其代谢基础可能是髓鞘形成的短暂紊乱。
