Lai Nanxi, Li Zhisheng, Xu Cenglin, Wang Yi, Chen Zhong
Institute of Pharmacology & Toxicology, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Neurobiol Dis. 2023 Feb;177:105999. doi: 10.1016/j.nbd.2023.105999. Epub 2023 Jan 10.
Interictal electroencephalogram (EEG) patterns, including high-frequency oscillations (HFOs), interictal spikes (ISs), and slow wave activities (SWAs), are defined as specific oscillations between seizure events. These interictal oscillations reflect specific dynamic changes in network excitability and play various roles in epilepsy. In this review, we briefly describe the electrographic characteristics of HFOs, ISs, and SWAs in the interictal state, and discuss the underlying cellular and network mechanisms. We also summarize representative evidence from experimental and clinical epilepsy to address their critical roles in ictogenesis and epileptogenesis, indicating their potential as electrophysiological biomarkers of epilepsy. Importantly, we put forwards some perspectives for further research in the field.
发作间期脑电图（EEG）模式，包括高频振荡（HFOs）、发作间期棘波（ISs）和慢波活动（SWAs），被定义为癫痫发作事件之间的特定振荡。这些发作间期振荡反映了网络兴奋性的特定动态变化，并在癫痫中发挥着各种作用。在本综述中，我们简要描述了发作间期状态下HFOs、ISs和SWAs的脑电图特征，并讨论了其潜在的细胞和网络机制。我们还总结了来自实验性和临床癫痫的代表性证据，以阐述它们在癫痫发作和癫痫发生中的关键作用，表明它们作为癫痫电生理生物标志物的潜力。重要的是，我们提出了该领域进一步研究的一些观点。
