Kiiatkin E A, Shamakina I Iu, Zhukov V N
Biull Eksp Biol Med. 1987 Sep;104(9):283-5.
Significant hypoalgesia (tail-flick reflex at 60 degrees C) was observed in rats during the whole period of 24-hour immobilization in cramped cages, as compared to food-and-water deprived and control animals. This hypoalgesia was not antagonized by naloxone (1 mg/kg), however, the animals periodically receiving the drug during immobilization revealed aggressiveness and significant hypoalgesia after immobilization was discontinued (30-120 min observation).
与禁食禁水及对照动物相比，在狭窄笼子中固定24小时的大鼠整个期间观察到显著的痛觉减退（60摄氏度时的甩尾反射）。然而，这种痛觉减退不能被纳洛酮（1毫克/千克）拮抗，不过，在固定期间定期接受该药物的动物在停止固定后（观察30 - 120分钟）表现出攻击性和显著的痛觉减退。
