Willer J C, Dehen H, Cambier J
Nouv Presse Med. 1982 Apr 17;11(18):1389-91.
The effects of a repetitive stress (expectation of severe pain) on the threshold of a nociceptive flexion reflex of the lower limb (Rlll, Bi) were investigated in normal subjects. A progressive and significant rise of the Rlll, Bi Threshold was observed as the stress was repeated several times over a 60 to 90 minutes' period. This effect was entirely reversed by naloxone, with fall of the threshold below initial values. In a double-blind test, the injection of a placebo had no significant effect on the reflex threshold when compared with control values. These results are in agreement with those reported in animals. They provide experimental evidence for an involvement of endogenous opiate systems in the mechanism of stress in normal subjects.
在正常受试者中，研究了重复性应激（预期严重疼痛）对下肢伤害性屈曲反射阈值（Rlll，Bi）的影响。在60至90分钟的时间段内重复施加应激时，观察到Rlll，Bi阈值逐渐且显著升高。纳洛酮可完全逆转这种效应，使阈值降至初始值以下。在双盲试验中，与对照值相比，注射安慰剂对反射阈值无显著影响。这些结果与动物研究报告的结果一致。它们为内源性阿片系统参与正常受试者的应激机制提供了实验证据。
