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[维生素E和胸腺素对实验性变态反应性脑脊髓炎发展的影响]

[Effect of vitamin E and thymalin on the development of experimental allergic encephalomyelitis].

作者信息

Vilkov G A, Stepanenko E M, Kryzhanovskiĭ G N

出版信息

Biull Eksp Biol Med. 1987 Sep;104(9):288-90.

PMID:3663910
Abstract

It has been established in the experiments on rats resistant to encephalomyelitis that vitamin E deficiency promoted and thymaline administration prevented the onset of the disease. The experiments on guinea-pigs sensitive to encephalomyelitis have shown that the combined administration of alpha-tocopherol and thymaline prevented the development of the disease. The results obtained make it possible to suggest that the resistance to encephalomyelitis depends on the level of membrane antioxidant defense and the condition of T-cell immunity.

摘要

在对抵抗脑脊髓炎的大鼠进行的实验中已证实,维生素E缺乏会促使疾病发作,而给予胸腺嘧啶可预防疾病发作。对易患脑脊髓炎的豚鼠进行的实验表明,联合给予α-生育酚和胸腺嘧啶可预防疾病发展。所获得的结果表明,对脑脊髓炎的抵抗力取决于膜抗氧化防御水平和T细胞免疫状况。

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