Kryzhanovskiĭ G N, Vilkov G A, Stepanenko E M
Biull Eksp Biol Med. 1984 Nov;98(11):527-30.
The authors studied the action of combined tocopherol, lithium hydroxybutyrate and pyridoxal phosphate on the development of experimental allergic encephalomyelitis (EAE) in guinea-pigs. The use of the combined drug from the first days of immunization with encephalitis-inducing material prevented the development of EAE, activation of lipid peroxidation (LPO), and the appearance of the blood serum neurotropic activity. Administration of the combined drug starting from the 7th day after immunization appeared ineffective as was the administration of each drug alone, starting from the first days of immunization. The data obtained support an important role of LPO activation for the pathogenesis of the neuroallergic process.
作者研究了生育酚、γ-羟基丁酸锂和磷酸吡哆醛联合使用对豚鼠实验性变应性脑脊髓炎（EAE）发展的作用。从用致脑炎物质免疫的第一天起使用联合药物可预防EAE的发展、脂质过氧化（LPO）的激活以及血清神经嗜性活性的出现。从免疫后第7天开始给予联合药物似乎无效，从免疫第一天起单独给予每种药物也是如此。所获得的数据支持LPO激活在神经变应性过程发病机制中的重要作用。
