Shcherbakova N M, Aleksandrova A E, Morozov V G, Podosinnikov I S, Khavinson V Kh
Biull Eksp Biol Med. 1981 Sep;92(9):320-2.
The effects were studied of the degree of immunodeficiency produced by thymectomy of one-month-old rats on the course of experimental tuberculosis induced 3, 6 and 9 months after thymectomy. Subject to study was also the effect of immunodeficiency correction with thymalin on the tuberculous process. It was established that the lungs of thymectomized rats infected 9 months after the thymectomy were damaged more severely as compared with control or thymalin-treated animals. In thymectomized rats treated with thymalin, the absolute content of medium-sized and big lymphocytes in peripheral blood was found to be lower, the content of small lymphocytes being unchanged throughout all observation periods. The time course of migration activity (spontaneous and in response to PPD) in rats treated with thymalin corresponded with the time course in controls in contrast to thymectomized rats which did not receive the treatment. The results indicate that tuberculosis severity depends on the degree of immunodeficiency and that the functional properties of immunocompetent cells may be corrected with thymalin.
研究了1月龄大鼠胸腺切除所产生的免疫缺陷程度对胸腺切除后3、6和9个月诱发的实验性结核病病程的影响。还研究了用胸腺素纠正免疫缺陷对结核过程的影响。结果表明，与对照或胸腺素治疗的动物相比，胸腺切除9个月后感染的大鼠肺部损伤更严重。在用胸腺素治疗的胸腺切除大鼠中，外周血中中等大小和大淋巴细胞的绝对含量较低，在所有观察期内小淋巴细胞的含量未发生变化。与未接受治疗的胸腺切除大鼠相比，用胸腺素治疗的大鼠迁移活性（自发和对结核菌素纯蛋白衍生物的反应）的时间进程与对照中的时间进程一致。结果表明，结核病的严重程度取决于免疫缺陷的程度，并且免疫活性细胞的功能特性可用胸腺素纠正。
