Department of Hematology and Oncology, The Children's Hospital of Zhejiang University School of Medicine, Zhejiang Pediatric Leukemia Diagnosis and Treatment Technology Center, National Pediatric Health and Disease Clinical Medical Research Center, Hangzhou, 310000, Zhejiang, China.
Department of Pediatrics, The Affiliated Hospital of Hangzhou Normal University, No. 126 Wenzhou Road, Gongchenqiao Street, Gongshu District, Hangzhou, 310000, Zhejiang, China.
Ital J Pediatr. 2023 Jan 14;49(1):7. doi: 10.1186/s13052-023-01409-8.
Quality sleep is essential for physical and mental health. We aimed to analyze sleep disorders in children with acute leukemia and explore associated factors.
General data and sleep disorders in children with acute leukemia during chemotherapy were collected by general questionnaires, Children's Sleep Disorders Scale and the Parenting Stress Index-short form.
In total, 173 valid questionnaires were collected. The total Sleep Disorder Scale score > 39 is considered a sleep disorder, while sleep disorders accounted for 45.66% (79/173). In the cohort, 167 children had acute lymphoblastic leukemia, with 40.12% (67/167) having sleep disorders, while six children had acute non-lymphoblastic leukemia, with 50.00% (3/6) having sleep disorders. Single- and multi-factor regression analyses of age, gender, number of children in the family, and time spent using electronic devices showed that factors influencing sleep disorders in these children were mainly parental scolding and adenoid hypertrophy. Children with sleep disorders had more parental stress than those without sleep disorders (P < 0.05).
The high incidence of sleep disorders in children with acute leukemia is related to airway conditions and parental behaviors. Sleep disorders in children can increase parenting stress. Factors potentially affecting sleep quality should be addressed as early as possible, while parental education should be strengthened to better facilitate the physical and psychological recovery of their children.
优质睡眠对身心健康至关重要。本研究旨在分析急性白血病患儿的睡眠障碍，并探讨相关因素。
通过一般问卷、儿童睡眠障碍量表和父母压力指数-短表收集化疗期间急性白血病患儿的一般资料和睡眠障碍。
共收集到 173 份有效问卷。总睡眠障碍量表评分>39 分被认为存在睡眠障碍，睡眠障碍发生率为 45.66%（79/173）。在队列中，167 例患儿患有急性淋巴细胞白血病，其中 40.12%（67/167）存在睡眠障碍，6 例患儿患有急性非淋巴细胞白血病，其中 50.00%（3/6）存在睡眠障碍。单因素和多因素回归分析显示，影响这些儿童睡眠障碍的因素主要是父母责骂和腺样体肥大。有睡眠障碍的儿童比没有睡眠障碍的儿童有更多的父母压力（P<0.05）。
急性白血病患儿睡眠障碍发生率高，与气道状况和父母行为有关。儿童睡眠障碍会增加父母的压力。应尽早解决潜在影响睡眠质量的因素，并加强对父母的教育，以更好地促进其子女的身心康复。
