Brown P P, Coalson J J, Elkins R C, Hinshaw L B, Greenfield L J
J Trauma. 1976 Mar;16(3):184-90. doi: 10.1097/00005373-197603000-00002.
The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in PAP and a decrease in LAP. This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only four of 17 animals although all endotoxin-treated swine showed interstitial edema and elevated wet/dry weight ratios with normal pulmonary surfactant. In addition, endotoxin-treated swine developed signs of disseminated intravascular coagulation, with renal cortical infarcts in 44%, and coronary arterial thrombi in 28% including one transmural myocardial infarction. This effect was observed in the absence of prolonged hypotension in swine and should provide a useful model for further study of the relationship of endotoxin to disseminated intravascular coagulation.
向清醒猪注射亚致死剂量的大肠杆菌推注量会导致肺动脉压（PAP）早期升高和左心房压（LAP）降低。这种血流动力学效应可能继发于其他物种中所见的肺静脉收缩，或者可能与已证实的多发性肺微栓子有关。尽管所有接受内毒素治疗的猪均出现间质水肿且湿/干重比升高，同时肺表面活性物质正常，但17只动物中只有4只出现低氧血症。此外，接受内毒素治疗的猪出现弥散性血管内凝血的体征，44%出现肾皮质梗死，28%出现冠状动脉血栓，其中包括1例透壁性心肌梗死。在猪未出现长时间低血压的情况下观察到了这种效应，这应为进一步研究内毒素与弥散性血管内凝血之间的关系提供一个有用的模型。
