美托洛尔或普萘洛尔使清醒自发性高血压大鼠肾交感神经活性增加。
Increase of renal sympathetic nerve activity by metoprolol or propranolol in conscious spontaneously hypertensive rats.
作者信息
Majcherczyk S, Mikulski A, Sjölander M, Thorén P
机构信息
Department of Pharmacology and Biochemistry, Hässle Cardiovascular Research Laboratories, Mölndal, Sweden.
出版信息
Br J Pharmacol. 1987 Aug;91(4):711-4. doi: 10.1111/j.1476-5381.1987.tb11267.x.
Abstract
1 Mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were recorded in conscious spontaneously hypertensive rats (SHR). 2 Infusion of metoprolol (4 mumol kg-1 h-1) or propranolol (1.5 mumol kg-1 h-1) reduced HR and significantly increased RSNA. 3 Administration of metoprolol caused a sustained decrease of MAP starting in the third hour of infusion. In contrast, administration of propranolol induced a biphasic response in MAP. It is suggested that the increase of RSNA after both beta-adrenoceptor blocking drugs is due to a decrease in arterial baroreceptor activity.
摘要
- 记录清醒自发性高血压大鼠（SHR）的平均动脉压（MAP）、心率（HR）和肾交感神经活动（RSNA）。2. 输注美托洛尔（4 μmol·kg⁻¹·h⁻¹）或普萘洛尔（1.5 μmol·kg⁻¹·h⁻¹）可降低心率并显著增加肾交感神经活动。3. 输注美托洛尔从第三小时开始使平均动脉压持续降低。相比之下，输注普萘洛尔引起平均动脉压双相反应。提示两种β肾上腺素受体阻断药后肾交感神经活动增加是由于动脉压力感受器活动降低所致。
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