丹曲林对正常甲状腺、甲状腺功能减退和甲状腺功能亢进大鼠慢肌和快肌力量发展的影响。
Effects of dantrolene on force development in slow- and fast-twitch muscle of euthyroid, hypothyroid, and hyperthyroid rats.
作者信息
Everts M E, van Hardeveld C
机构信息
Department of Chemical Pathology, University Hospital Leiden, The Netherlands.
出版信息
Br J Pharmacol. 1987 Sep;92(1):47-54. doi: 10.1111/j.1476-5381.1987.tb11294.x.
Abstract
1 The effects of dantrolene on twitch and tetanic force development were determined in soleus and gastrocnemius muscle of euthyroid, hypothyroid, and hyperthyroid rats. 2 Maximum twitch force of the gastrocnemius muscle was significantly more depressed by dantrolene than that of the soleus muscle in euthyroid and hyperthyroid rats. In hypothyroid rats, the effect of dantrolene on maximum twitch force was similar in soleus and gastrocnemius muscle. 3 Maximum tetanic force in soleus and gastrocnemius muscle was less depressed by dantrolene than the twitch force in either thyroid state. The effect of dantrolene on maximum tetanic force increased in both muscles in the direction hypothyroid----euthyroid----hyperthryoid. 4 The results are discussed in terms of an effect of thyroid hormones on Ca2+ -cycling during force development, as a result of thyroid hormone-induced proliferation of the sarcoplasmic reticulum.
摘要
- 在甲状腺功能正常、甲状腺功能减退和甲状腺功能亢进的大鼠的比目鱼肌和腓肠肌中，测定了丹曲林对单收缩和强直收缩力量发展的影响。2. 在甲状腺功能正常和甲状腺功能亢进的大鼠中，丹曲林对腓肠肌最大单收缩力量的抑制作用明显大于比目鱼肌。在甲状腺功能减退的大鼠中，丹曲林对最大单收缩力量的影响在比目鱼肌和腓肠肌中相似。3. 在两种甲状腺状态下，丹曲林对比目鱼肌和腓肠肌最大强直收缩力量的抑制作用均小于对单收缩力量的抑制作用。丹曲林对最大强直收缩力量的影响在两种肌肉中均按照甲状腺功能减退----甲状腺功能正常----甲状腺功能亢进的方向增加。4. 根据甲状腺激素对力量发展过程中Ca2+循环的影响，以及甲状腺激素诱导的肌浆网增殖的结果，对这些结果进行了讨论。
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