甲状腺激素对快、慢骨骼肌肌浆网Ca-ATP酶同工酶的mRNA水平有不同影响。
Thyroid hormone differentially affects mRNA levels of Ca-ATPase isozymes of sarcoplasmic reticulum in fast and slow skeletal muscle.
作者信息
Simonides W S, van der Linden G C, van Hardeveld C
机构信息
Laboratory for Physiology, Free University, Amsterdam, The Netherlands.
出版信息
FEBS Lett. 1990 Nov 12;274(1-2):73-6. doi: 10.1016/0014-5793(90)81332-i.
mRNA levels for the type I and type II isoforms of sarcoplasmic reticulum (SR) Ca-ATPase were determined in soleus (SOL) and extensor digitorum longus (EDL) muscle of euthyroid (normal), hypothyroid, and hyperthyroid rats. Total Ca-ATPase mRNA content of hyperthyroid muscle was 1.5-fold (EDL) and 6-fold (SOL) higher compared to hypothyroid muscle, with corresponding increases in total SR Ca-ATPase activity. EDL contained only type II Ca-ATPase mRNA. In SOL type I mRNA was the major form in hypothyroidism (98%), but the type II mRNA content was stimulated 150-fold by T3, accounting for 50% of the Ca-ATPase mRNA in hyperthyroidism.
在甲状腺功能正常（正常）、甲状腺功能减退和甲状腺功能亢进的大鼠的比目鱼肌（SOL）和趾长伸肌（EDL）中，测定了肌浆网（SR）Ca - ATP酶I型和II型同工型的mRNA水平。与甲状腺功能减退的肌肉相比，甲状腺功能亢进的肌肉的总Ca - ATP酶mRNA含量高1.5倍（EDL）和6倍（SOL），同时总SR Ca - ATP酶活性也相应增加。EDL仅含有II型Ca - ATP酶mRNA。在SOL中，I型mRNA在甲状腺功能减退时是主要形式（98%），但II型mRNA含量被T3刺激了150倍，在甲状腺功能亢进时占Ca - ATP酶mRNA的50%。
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