Lotter Leon D, Kohl Simon H, Gerloff Christian, Bell Laura, Niephaus Alexandra, Kruppa Jana A, Dukart Juergen, Schulte-Rüther Martin, Reindl Vanessa, Konrad Kerstin
Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital RWTH Aachen, Aachen, Germany; Institute of Neuroscience and Medicine - Brain & Behaviour (INM-7), Jülich Research Centre, Jülich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Max Planck School of Cognition, Stephanstrasse 1A, 04103 Leipzig, Germany.
Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital RWTH Aachen, Aachen, Germany; JARA Brain Institute II, Molecular Neuroscience and Neuroimaging (INM-11), Jülich Research Centre, Jülich, Germany.
Neurosci Biobehav Rev. 2023 Mar;146:105042. doi: 10.1016/j.neubiorev.2023.105042. Epub 2023 Jan 11.
Humans synchronize with one another to foster successful interactions. Here, we use a multimodal data fusion approach with the aim of elucidating the neurobiological mechanisms by which interpersonal neural synchronization (INS) occurs. Our meta-analysis of 22 functional magnetic resonance imaging and 69 near-infrared spectroscopy hyperscanning experiments (740 and 3721 subjects) revealed robust brain regional correlates of INS in the right temporoparietal junction and left ventral prefrontal cortex. Integrating this meta-analytic information with public databases, biobehavioral and brain-functional association analyses suggested that INS involves sensory-integrative hubs with functional connections to mentalizing and attention networks. On the molecular and genetic levels, we found INS to be associated with GABAergic neurotransmission and layer IV/V neuronal circuits, protracted developmental gene expression patterns, and disorders of neurodevelopment. Although limited by the indirect nature of phenotypic-molecular association analyses, our findings generate new testable hypotheses on the neurobiological basis of INS.
人类相互同步以促进成功的互动。在此，我们采用多模态数据融合方法，旨在阐明人际神经同步（INS）发生的神经生物学机制。我们对22项功能磁共振成像和69项近红外光谱超扫描实验（分别涉及740名和3721名受试者）的荟萃分析显示，INS在右侧颞顶联合区和左侧腹侧前额叶皮质有强大的脑区相关性。将这一荟萃分析信息与公共数据库相结合，生物行为和脑功能关联分析表明，INS涉及与心理化和注意力网络有功能连接的感觉整合枢纽。在分子和遗传水平上，我们发现INS与γ-氨基丁酸能神经传递、IV/ V层神经元回路、长期发育基因表达模式以及神经发育障碍有关。尽管受到表型-分子关联分析间接性质的限制，但我们的发现为INS的神经生物学基础提出了新的可检验假设。
