Ogien Jonas, Daures Anthony, Cazalas Maxime, Perrot Jean-Luc, Dubois Arnaud
DAMAE Medical, Paris, 75013, France.
CHU St-Etienne, Service Dermatologie, Saint-Etienne, 42055, France.
Front Optoelectron. 2020 Dec;13(4):381-392. doi: 10.1007/s12200-020-1096-x. Epub 2020 Dec 23.
This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal (x × y) section images at an adjustable depth or vertical (x × z) section images at an adjustable lateral position, as well as three-dimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions. Three-dimensional (x × y × z) images are acquired from a stack of horizontal section images. The device is in the form of a portable probe. The handle of the probe has a button and a scroll wheel allowing the user to control the imaging modes. Using a supercontinuum laser as a broadband light source and a high numerical microscope objective, an isotropic spatial resolution of ∼1 µm is achieved. The field of view of the three-dimensional images is 1.2 mm × 0.5 mm × 0.5 mm (x × y × z). Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.
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