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牙科学生对克兰费尔特综合征的了解与认识。

Knowledge and awareness of the Klinefelter Syndrome among the dental students.

作者信息

Ram Ashwin Jaikumar, Veeraraghavan Vishnupriya, Selvaraj J, Gayathri R, Kavitha S

机构信息

Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

出版信息

J Adv Pharm Technol Res. 2022 Nov;13(Suppl 1):S342-S347. doi: 10.4103/japtr.japtr_384_22. Epub 2022 Nov 30.

DOI:10.4103/japtr.japtr_384_22
PMID:36643165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9836104/
Abstract

The presence of one or more extra X chromosomes in a male causes Klinefelter Syndrome (KS). KS affects 1 in 500-1 in 1000 men, while about half remain undiagnosed. KS is characterized by huge stature, increase in arm length, the feminine distribution of adipose tissues (including gynecomastia), less or pubic hair, infertility, hypotonia, reduced size of penis and less than average verbal IQ, struggle in learning and requirements for less specified speech therapy. KS is a primary testicular insufficiency with high levels of gonadotropin caused by a lack of pituitary gland feedback. The aim of the study is to assess the knowledge and awareness of the KS among the dental students. This cross-sectional survey was conducted among dental students of a private dental hospital. To evaluate the knowledge and awareness of the participants about KS, a self-administered questionnaire consisting of 10 questions was prepared. Percentage analysis and frequency analysis and percentage analysis were performed. A Chi-square test was done to assess the correlation using the SPSS software. In our study, most of the participants were aware of the KS. They also knew that the KS is caused due to the additional X chromosome. We would like to conclude that the dental students were much aware about the Klinefelter and they also had a thorough knowledge about it.

摘要

男性体内若存在一条或多条额外的X染色体，会导致克氏综合征（KS）。每500至1000名男性中就有1人受KS影响，约半数患者仍未被诊断出来。KS的特征包括身材高大、手臂长度增加、脂肪组织呈女性化分布（包括男性乳房发育）、阴毛减少或稀疏、不育、肌张力减退、阴茎尺寸减小以及语言智商低于平均水平、学习困难且需要不太特定的言语治疗。KS是一种原发性睾丸功能不全，由垂体反馈缺失导致促性腺激素水平升高。本研究的目的是评估牙科学生对KS的了解和认识。这项横断面调查是在一家私立牙科医院的牙科学生中进行的。为评估参与者对KS的了解和认识，准备了一份包含10个问题的自填式问卷。进行了百分比分析、频率分析以及百分比分析。使用SPSS软件进行卡方检验以评估相关性。在我们的研究中，大多数参与者了解KS。他们也知道KS是由额外的X染色体引起的。我们得出结论，牙科学生对克氏综合征了解很多，并且对此也有深入的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1008/9836104/b30a8bfe4654/JAPTR-13-342-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1008/9836104/b30a8bfe4654/JAPTR-13-342-g009.jpg
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The impact of Klinefelter syndrome on socioeconomic status: a multicenter study.克兰费尔特综合征对社会经济地位的影响：一项多中心研究。
Endocr Connect. 2022 Jun 29;11(7). doi: 10.1530/EC-22-0010. Print 2022 Jul 1.
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Onset and progression of puberty in Klinefelter syndrome.克兰费尔特综合征中青春期的 onset 和进展。（这里“onset”结合语境准确含义还需进一步明确，比如可译为“起始”等）
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Klinefelter Syndrome and Turner Syndrome.克兰费尔特综合征和特纳综合征。
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The effect of early hormonal treatment (EHT) on expressive and receptive language capabilities in boys with 47,XXY (Klinefelter syndrome) during infancy and early childhood.早期激素治疗（EHT）对婴儿期和幼儿期 47,XXY（克莱恩费尔特综合征）男孩表达和接受语言能力的影响。
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