唾液微小RNA与口腔潜在恶性疾病发生及进展的关联：寻找非侵入性生物标志物
Association of salivary miRNAs with onset and progression of oral potentially malignant disorders: Searching for noninvasive biomarkers.
作者信息
Liu Wei, Shi Huan, Zhou Zengtong, Zhang Chenping, Shen Xuemin
机构信息
Department of Stomatology, Fengcheng Hospital of Fengxian District, Shanghai Ninth People's Hospital Fengcheng Branch Hospital, Shanghai, China.
College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
出版信息
J Dent Sci. 2023 Jan;18(1):432-436. doi: 10.1016/j.jds.2022.08.002. Epub 2022 Aug 20.
BACKGROUND/PURPOSE: There is an urgent need for noninvasive biomarkers to diagnose oral potentially malignant disorders (OPMD). A wide range of over 20 miRNAs in saliva of OPMD patients have been investigated in different studies. Yet, which of the ones provide a better power of discrimination for the diagnosis of OPMD onset and progression are uncertain.
MATERIALS AND METHODS
A total of 17 eligible studies including 426 cases of OPMD and 486 control subjects (352 normal mucosa and 134 oral squamous cell carcinoma) were summarized.
RESULTS
The bubble chart analysis showed that the most power salivary miRNA associated with OPMD onset was miR-21, followed by miR-31 and miR-142; the better power miRNAs associated with recurrence and malignant progression of OPMD were miR-31, miR-21, and miR-184.
CONCLUSION
Salivary miRNAs, especially miR-21 and miR-31, were associated with onset and progression of OPMD, and could then serve as noninvasive biomarkers for screening OPMD and detecting malignant changes.
背景/目的：迫切需要非侵入性生物标志物来诊断口腔潜在恶性疾病（OPMD）。在不同研究中，已对OPMD患者唾液中20多种miRNA进行了广泛研究。然而，其中哪些miRNA对OPMD的发生和进展具有更好的鉴别能力尚不确定。
材料与方法
共总结了17项符合条件的研究，包括426例OPMD患者和486例对照受试者（352例正常黏膜和134例口腔鳞状细胞癌）。
结果
气泡图分析显示，与OPMD发生相关的唾液miRNA中，miR-21的鉴别能力最强，其次是miR-31和miR-142；与OPMD复发和恶性进展相关的miRNA中，miR-31、miR-21和miR-184的鉴别能力较好。
结论
唾液miRNA，尤其是miR-21和miR-31，与OPMD的发生和进展相关，可作为筛查OPMD和检测恶性变化的非侵入性生物标志物。
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