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口腔潜在恶性疾病细胞刷检样本中异常的、、和表达。 （你提供的原文中存在部分缺失内容，这可能会影响翻译的准确性和完整性。）

Aberrant , , and expression in the cytobrushed samples from oral potentially malignant disorders.

作者信息

Tu Hsi-Feng, Chang Kuo-Wei, Lin Shu-Chun, Hung Wan-Wen, Ji Si-Hua, Wu Hsiao-Li, Liu Chung-Ji

机构信息

Department of Dentistry, National Yang Ming Chiao Tung Hospital, Yi-Lan, Taiwan.

Department of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

J Dent Sci. 2022 Apr;17(2):688-695. doi: 10.1016/j.jds.2021.07.010. Epub 2021 Jul 30.

DOI:10.1016/j.jds.2021.07.010
PMID:35756791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9201535/
Abstract

BACKGROUND/PURPOSE: MicroRNA (miRNA) alterations play important roles in the neoplastic process of oral squamous cell carcinoma (OSCC). Upregulation of and and downregulation of are frequent events in OSCC. The aberrances of these miRNAs in oral potentially malignant lesions (OPMD) were studied to determine their status during the establishment of OSCC.

MATERIALS AND METHODS

Cytobrushed sampling was used to collect epithelial cells from 11 OSCC and 34 OPMD lesions and matched normal mucosa. The expression levels of , , and were analyzed using quantitative reverse transcription polymerase chain reaction analysis. The clinical implications of these aberrances were further investigated.

RESULTS

Both and were upregulated in OPMD, but only expression was upregulated in OSCC comparing to control. was downregulated in OPMD and tended to be downregulated in OSCC. Dysplastic OPMD could be distinguished based on expression level; expression levels facilitated discrimination between OPMD and OSCC. The combined analysis of and remarkably enhanced the accuracy of differentiating OPMD from OSCC.

CONCLUSION

Aberrant . , and expression occurs early during oral carcinogenesis. The detection of and expression using cytobrush samples may assist in differentiating between OPMD and OSCC.

摘要

背景/目的：微小RNA（miRNA）改变在口腔鳞状细胞癌（OSCC）的肿瘤发生过程中起重要作用。miR-181b和miR-21上调以及miR-34a下调在OSCC中是常见事件。研究这些miRNA在口腔潜在恶性病变（OPMD）中的异常情况，以确定它们在OSCC发生过程中的状态。

材料与方法

采用细胞刷采样法从11例OSCC和34例OPMD病变以及匹配的正常黏膜中收集上皮细胞。使用定量逆转录聚合酶链反应分析来检测miR-181b、miR-21和miR-34a的表达水平。进一步研究这些异常情况的临床意义。

结果

miR-181b和miR-21在OPMD中均上调，但与对照相比，仅miR-21在OSCC中的表达上调。miR-34a在OPMD中下调，在OSCC中呈下调趋势。发育异常的OPMD可根据miR-34a表达水平进行区分；miR-181b表达水平有助于区分OPMD和OSCC。miR-181b和miR-34a的联合分析显著提高了区分OPMD和OSCC的准确性。

结论

miR-181b、miR-21和miR-34a表达异常发生在口腔癌发生的早期。使用细胞刷样本检测miR-181b和miR-34a表达可能有助于区分OPMD和OSCC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/9341494ca9b0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/cade4baa290a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/9e5505e50da3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/77009b6e1bf2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/e953761a573f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/3764b02bea16/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/586b91a7c234/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/9341494ca9b0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/cade4baa290a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/9e5505e50da3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/77009b6e1bf2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/e953761a573f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/3764b02bea16/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/586b91a7c234/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50c6/9201535/9341494ca9b0/gr7.jpg

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2
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Int J Mol Sci. 2020 Dec 11;21(24):9442. doi: 10.3390/ijms21249442.
3
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Cancers (Basel). 2024 Apr 13;16(8):1492. doi: 10.3390/cancers16081492.
4
Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications.口腔癌中的非编码RNA：新兴作用与临床应用
Cancers (Basel). 2023 Jul 25;15(15):3752. doi: 10.3390/cancers15153752.
5
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Int J Mol Sci. 2020 Sep 18;21(18):6853. doi: 10.3390/ijms21186853.
4
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5
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6
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