Sica G, Natoli V, Stella C, Del Bianco S
Istituto di Istologia ed Embriologia Generale, Università Cattolica del S. Cuore, Rome, Italy.
Cancer. 1987 Nov 15;60(10):2419-23. doi: 10.1002/1097-0142(19871115)60:10<2419::aid-cncr2820601011>3.0.co;2-s.
The effect of natural beta-interferon (beta-IFN) on cell proliferation and steroid receptor level was investigated in CG-5 human breast cancer cell line. beta-interferon determines an appreciable diminution of cell growth, at concentrations ranging from 100 to 1000 IU/ml, which is enhanced when serum content of the culture medium is lowered. Low concentrations of beta-IFN (10-100 IU/ml) produce, after a 5-day treatment, an increase in estrogen receptors (ER) and progesterone receptors (PR). No variation of ER and PR levels is observed when beta-IFN is added directly to the cell homogenate before the assay. Our data suggest that beta-IFN could affect hormone sensitivity through a modification of ER and PR in neoplastic mammary cells.
在CG-5人乳腺癌细胞系中研究了天然β-干扰素（β-IFN）对细胞增殖和类固醇受体水平的影响。β-干扰素在浓度为100至1000 IU/ml时可使细胞生长明显减少，当培养基的血清含量降低时这种作用增强。低浓度的β-干扰素（10 - 100 IU/ml）在处理5天后可使雌激素受体（ER）和孕激素受体（PR）增加。在测定前将β-干扰素直接添加到细胞匀浆中时，未观察到ER和PR水平的变化。我们的数据表明，β-干扰素可能通过改变肿瘤乳腺细胞中的ER和PR来影响激素敏感性。
