De Cicco F, Sica G, Benedetto M T, Ciabattoni G, Rossiello F, Nicosia A, Lupi G, Iacopino F, Mancuso S, Dell'Acqua S
Department of Obstetrics, Universita' Cattolica del S. Cuore, Rome, Italy.
J Steroid Biochem. 1988;30(1-6):359-62. doi: 10.1016/0022-4731(88)90123-9.
The effect of natural beta-interferon (beta-IFN) on steroid receptor levels and output of prostaglandins (PGs) was investigated in human endometrial cancer. beta-IFN determines in endometrial adenocarcinoma explants an increase of cytosolic estradiol (ER) and progesterone (PR) receptors at concentrations ranging from 10 to 1000 IU/ml of culture medium. Only cases in which there was an enhancement of at least 50% with respect to control values were considered. Low concentrations of beta-IFN (10 IU/ml of culture medium) produce an enhancement of ER in 60% and of PR in 42% of cases, while higher concentrations of beta-IFN (1000 IU/ml of culture medium) produce an enhancement of ER in 32%, and of PR in 82% of cases. Since PGs are involved in proliferation control in a large variety of tumors, we evaluated the ratio between PGF2-alpha and PGE2 levels in culture medium. This ratio increased, in our experimental model, after treatment with 10 and 1000 IU/ml of beta-IFN in 38% and 58% of cases respectively. Our data suggest that beta-IFN could affect cellular hormone sensitivity through a modification of ER and PR and it can also determine a variation of PG output in human endometrial cancer.
研究了天然β-干扰素（β-IFN）对人子宫内膜癌中类固醇受体水平和前列腺素（PGs）分泌的影响。β-IFN在子宫内膜腺癌外植体中，当培养基浓度为10至1000 IU/ml时，可使胞质雌二醇（ER）和孕酮（PR）受体增加。仅考虑相对于对照值至少增加50%的病例。低浓度的β-IFN（10 IU/ml培养基）在60%的病例中使ER增加，在42%的病例中使PR增加，而高浓度的β-IFN（1000 IU/ml培养基）在32%的病例中使ER增加，在82%的病例中使PR增加。由于PGs参与多种肿瘤的增殖控制，我们评估了培养基中PGF2-α与PGE2水平的比值。在我们的实验模型中，分别用10和1000 IU/ml的β-IFN处理后，该比值在38%和58%的病例中增加。我们的数据表明，β-IFN可能通过改变ER和PR来影响细胞激素敏感性，并且它还可以决定人子宫内膜癌中PG分泌的变化。
