与肝素抗凝血酶III结合位点相对应的五糖构象。 - Suppr

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超能文献

Conformation of the pentasaccharide corresponding to the binding site of heparin to antithrombin-III.

作者信息

Ragazzi M, Ferro D R, Perly B, Torri G, Casu B, Sinaÿ P, Petitou M, Choay J

机构信息

Istituto di Chimica delle Macromolecole del CNR, Milano, Italy.

出版信息

Carbohydr Res. 1987 Jul 15;165(1):c1-5. doi: 10.1016/0008-6215(87)80093-9.

DOI:10.1016/0008-6215(87)80093-9

PMID:3664518

Abstract

摘要

相似文献

Conformation of the pentasaccharide corresponding to the binding site of heparin to antithrombin-III.与肝素抗凝血酶III结合位点相对应的五糖构象。

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A new synthetic pentasaccharide with increased anti-factor Xa activity: possible role for anionic clusters in the interaction of heparin and antithrombin III.一种具有增强抗Xa因子活性的新型合成五糖：阴离子簇在肝素与抗凝血酶III相互作用中的可能作用。

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Conformation of heparin pentasaccharide bound to antithrombin III.与抗凝血酶III结合的肝素五糖的构象

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Conformation of the pentasaccharide corresponding to the binding site of heparin for antithrombin III.对应于肝素抗凝血酶III结合位点的五糖的构象。

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Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity.抗凝血酶反应中心精氨酸的肝素依赖性修饰及随后肝素结合亲和力的增加。

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Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin.通过代表肝素与抗凝血酶结合位点的合成五糖，抗凝血酶介导对因子VIIa-组织因子复合物的抑制作用。

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Examination, by 1H-n.m.r. spectroscopy, of the binding of a synthetic, high-affinity heparin pentasaccharide to human antithrombin III.

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Conformational transitions induced in heparin octasaccharides by binding with antithrombin III.抗凝血酶III与肝素八糖结合诱导的构象转变

Biochem J. 2006 Oct 15;399(2):191-8. doi: 10.1042/BJ20060656.

The oligosaccharide side chain on Asn-135 of alpha-antithrombin, absent in beta-antithrombin, decreases the heparin affinity of the inhibitor by affecting the heparin-induced conformational change.α-抗凝血酶Asn-135位点上的寡糖侧链（β-抗凝血酶中不存在）通过影响肝素诱导的构象变化降低了该抑制剂对肝素的亲和力。

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A mechanism for heparin-induced potentiation of antithrombin III.肝素诱导抗凝血酶III增强作用的机制。

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