College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, 541004, China.
Anal Methods. 2023 Feb 2;15(5):626-630. doi: 10.1039/d2ay02026b.
Silver(I) ions (Ag) are harmful to humans and can be bioaccumulated in organisms. Although numerous methods for Ag analysis have been established, new strategies are still in urgent need. Here, we propose a colorimetric sensor based on polyadenine (polyA)-mediated DNA-functionalized gold nanoparticles (AuNPs) for the specific measurement of Ag ions. In this strategy, a polyA-modified Au probe with high uniformity was assembled successfully. The method was based on Ag-induced aggregation of the probe. Ag was reflected according to the color variations of solution. Taking advantage of the low cost and convenient assembly of the polyA-based Au probe, our strategy determined Ag with high sensitivity and wide range. In addition, by changing probes or nanoparticles, the proposed strategy is expected to be a universal platform for detecting other analytes in environmental and even biological samples.
银（I）离子（Ag）对人体有害，并能在生物体内累积。虽然已经建立了许多用于 Ag 分析的方法，但仍迫切需要新的策略。在这里，我们提出了一种基于聚腺嘌呤（polyA）介导的 DNA 功能化金纳米粒子（AuNPs）的比色传感器，用于特异性测量 Ag 离子。在该策略中，成功组装了具有高均一性的聚 A 修饰的 Au 探针。该方法基于探针的 Ag 诱导聚集。Ag 被根据溶液颜色变化来反映。利用基于 polyA 的 Au 探针的低成本和方便组装的特点，我们的策略具有高灵敏度和宽检测范围。此外，通过改变探针或纳米粒子，预计所提出的策略将成为用于检测环境甚至生物样品中其他分析物的通用平台。
