Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, Poland.
Angew Chem Int Ed Engl. 2023 Mar 1;62(10):e202217658. doi: 10.1002/anie.202217658. Epub 2023 Jan 31.
Hyperbranched polymethacrylates were synthesized by green-light-induced atom transfer radical polymerization (ATRP) under biologically relevant conditions in the open air. Sodium 2-bromoacrylate (SBA) was prepared in situ from commercially available 2-bromoacrylic acid and used as a water-soluble inibramer to induce branching during the copolymerization of methacrylate monomers. As a result, well-defined branched polymethacrylates were obtained in less than 30 min with predetermined molecular weights (36 000<M <170 000), tunable degree of branching, and low dispersity values (1.14≤Đ≤1.33). Moreover, the use of SBA inibramer enabled the synthesis of bioconjugates with a well-controlled branched architecture.
在开放条件下，利用生物相关条件下的绿光诱导原子转移自由基聚合（ATRP）合成了超支化聚甲基丙烯酸酯。通过将市售的 2-溴代丙烯酸原位制备为水溶性引发剂，在甲基丙烯酸酯单体共聚过程中诱导支化，从而在不到 30 分钟的时间内获得了具有预定分子量（36000<M <170000）、可调支化度和低分散度值（1.14≤Đ≤1.33）的超支化聚甲基丙烯酸酯。此外，使用 SBA 引发剂能够合成具有良好控制的支化结构的生物缀合物。
