IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy.
Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Trends Cancer. 2023 Mar;9(3):212-222. doi: 10.1016/j.trecan.2022.12.006. Epub 2023 Jan 14.
Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the potential to improve healthspan and decrease the incidence of cancer and other age-related diseases. Unlike chronic dietary restrictions or water-only fasting, FMDs represent safer and less challenging options for cancer patients. FMD cycles increase protection in healthy cells while sensitizing cancer cells to various therapies, partly by generating complex environments that promote differential stress resistance (DSR) and differential stress sensitization (DSS), respectively. More recent data indicate that FMD cycles enhance the efficacy of a range of drugs targeting different cancers in mice by stimulating antitumor immunity. Here, we report on the effects of FMD cycles on cancer prevention and treatment and the mechanisms implicated in these effects.
间歇性禁食模拟饮食（FMDs）作为一种有效的饮食干预措施正在兴起，具有改善健康寿命和降低癌症和其他与年龄相关疾病发病率的潜力。与慢性饮食限制或仅饮水禁食不同，FMD 是癌症患者更安全、更具挑战性的选择。FMD 周期增加了健康细胞的保护，同时使癌细胞对各种治疗方法敏感，部分原因是产生了分别促进差异化应激抵抗（DSR）和差异化应激敏感化（DSS）的复杂环境。最近的数据表明，FMD 周期通过刺激抗肿瘤免疫来增强针对不同癌症的一系列药物在小鼠中的疗效。在这里，我们报告了 FMD 周期对癌症预防和治疗的影响以及这些影响所涉及的机制。
