• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing.

作者信息

Marchetti Francesco, Cardoso Renato, Chen Connie L, Douglas George R, Elloway Joanne, Escobar Patricia A, Harper Tod, Heflich Robert H, Kidd Darren, Lynch Anthony M, Myers Meagan B, Parsons Barbara L, Salk Jesse J, Settivari Raja S, Smith-Roe Stephanie L, Witt Kristine L, Yauk Carole, Young Robert R, Zhang Shaofei, Minocherhomji Sheroy

出版信息

Nat Rev Drug Discov. 2023 Mar;22(3):165-166. doi: 10.1038/d41573-023-00014-y.

DOI:10.1038/d41573-023-00014-y
PMID:36646809
Abstract
摘要

相似文献

1
Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing.纠错下一代测序技术推动非临床遗传毒性和致癌性检测。
Nat Rev Drug Discov. 2023 Mar;22(3):165-166. doi: 10.1038/d41573-023-00014-y.
2
A decision tree-based integrated testing strategy for tailor-made carcinogenicity evaluation of test substances using genotoxicity test results and chemical spaces.一种基于决策树的综合测试策略,用于利用遗传毒性测试结果和化学空间对测试物质进行量身定制的致癌性评估。
Mutagenesis. 2019 Mar 6;34(1):101-109. doi: 10.1093/mutage/gey039.
3
N-vinyl compounds: studies on metabolism, genotoxicity, carcinogenicity.N-乙烯基化合物:代谢、遗传毒性、致癌性研究。
Arch Toxicol. 2021 Oct;95(10):3143-3159. doi: 10.1007/s00204-021-03081-5. Epub 2021 Jun 6.
4
Dynamically monitoring cellular γ-H2AX reveals the potential of carcinogenicity evaluation for genotoxic compounds.动态监测细胞 γ-H2AX 可揭示遗传毒性化合物致癌性评估的潜力。
Arch Toxicol. 2021 Nov;95(11):3559-3573. doi: 10.1007/s00204-021-03156-3. Epub 2021 Sep 12.
5
The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity.致癌基因组计划:化学干扰的体外基因表达谱分析预测长期致癌性。
Environ Health Perspect. 2019 Apr;127(4):47002. doi: 10.1289/EHP3986.
6
Genotoxicity and carcinogenicity testing of pharmaceuticals: correlations between induction of DNA lesions and carcinogenic activity.药品的遗传毒性和致癌性测试:DNA 损伤的诱导与致癌活性之间的相关性。
Mutat Res. 2010 Jul-Sep;705(1):20-39. doi: 10.1016/j.mrrev.2010.02.004. Epub 2010 Mar 3.
7
Genotoxicity and carcinogenicity studies of antihypertensive agents.抗高血压药物的遗传毒性和致癌性研究。
Mutat Res. 2006 Mar;612(2):115-49. doi: 10.1016/j.mrrev.2005.12.002. Epub 2006 Feb 7.
8
High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?突变检测中的高通量测序:新一代遗传毒性测试?
Mutat Res. 2015 Jun;776:136-43. doi: 10.1016/j.mrfmmm.2015.03.014. Epub 2015 Apr 20.
9
EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Negative Results in the Ames Test: Construction of the Database.欧洲替代方法验证参考实验室(EURL ECVAM)在艾姆斯试验中呈阴性结果的物质遗传毒性和致癌性数据库:数据库的构建
Mutat Res Genet Toxicol Environ Mutagen. 2020 Jun-Jul;854-855:503199. doi: 10.1016/j.mrgentox.2020.503199. Epub 2020 May 21.
10
Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk.下一代遗传毒理学:利用现代测序技术评估体细胞突变和癌症风险。
Environ Mol Mutagen. 2020 Jan;61(1):135-151. doi: 10.1002/em.22342. Epub 2019 Nov 11.

引用本文的文献

1
Quantitative genotoxicity assessment of N-nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination.通过纠错下一代测序和DNA甲基化定量分析对小鼠体内N-亚硝基二甲胺进行定量遗传毒性评估以确定毒性阈值。
Arch Toxicol. 2025 Aug 24. doi: 10.1007/s00204-025-04166-1.
2
Whole genome mutagenicity evaluation using Hawk-Seq™ demonstrates high inter-laboratory reproducibility and concordance with the transgenic rodent gene mutation assay.使用Hawk-Seq™进行的全基因组致突变性评估显示出较高的实验室间再现性,并与转基因啮齿动物基因突变试验结果一致。
Genes Environ. 2025 Jul 29;47(1):13. doi: 10.1186/s41021-025-00336-w.
3

本文引用的文献

1
Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing.使用人源体外器官型气道培养物进行遗传毒性测试:使用彗星芯片评估 DNA 损伤和双链测序评估诱变作用。
Environ Mol Mutagen. 2021 Jun;62(5):306-318. doi: 10.1002/em.22444. Epub 2021 Jun 14.
2
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.利用双链测序直接定量体内诱变和致癌作用。
Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33414-33425. doi: 10.1073/pnas.2013724117. Epub 2020 Dec 14.
3
Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.
Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis.
通过纠错下一代测序(ecNGS)和基准剂量(BMD)分析,结合量子力学(QM)建模和细胞色素P450(CYP)对接分析,推导N-亚硝基比索洛尔的安全限量。
Arch Toxicol. 2025 Jun 11. doi: 10.1007/s00204-025-04103-2.
4
Nitrosamine Drug Substance-Related Impurities (NDSRIs) in Pharmaceuticals: Formation, Mitigation Strategies, and Emphasis on Mutagenicity Risks.药品中的亚硝胺类原料药相关杂质(NDSRIs):形成、缓解策略及对致突变性风险的关注
Pharm Res. 2025 Apr;42(4):547-578. doi: 10.1007/s11095-025-03857-9. Epub 2025 Apr 23.
5
Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints.体内诱变性终点的基准反应(BMR)值。
Environ Mol Mutagen. 2025 Apr;66(4):172-184. doi: 10.1002/em.70006. Epub 2025 Apr 4.
6
Duplex sequencing identifies unique characteristics of ENU-induced mutations in male mouse germ cells†.双链测序鉴定雄性小鼠生殖细胞中ENU诱导突变的独特特征†
Biol Reprod. 2025 May 13;112(5):1015-1027. doi: 10.1093/biolre/ioaf029.
7
Effect of sequencing platforms on the sensitivity of chemical mutation detection using Hawk-Seq™.测序平台对使用Hawk-Seq™进行化学突变检测灵敏度的影响。
Genes Environ. 2024 Oct 9;46(1):20. doi: 10.1186/s41021-024-00313-9.
8
Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment.制定一种务实的共识程序,以支持国际人用药品注册技术协调会S1B(R1)证据权重致癌性评估。
Front Toxicol. 2024 Apr 5;6:1370045. doi: 10.3389/ftox.2024.1370045. eCollection 2024.
9
Effects of urban-induced mutations on ecology, evolution and health.城市诱发突变对生态、进化和健康的影响。
Nat Ecol Evol. 2024 Jun;8(6):1074-1086. doi: 10.1038/s41559-024-02401-z. Epub 2024 Apr 19.
10
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing.使用纠错的下一代测序技术评估 N-亚硝基二甲胺在 2D 和 3D HepaRG 细胞培养物中的致突变性。
Arch Toxicol. 2024 Jun;98(6):1919-1935. doi: 10.1007/s00204-024-03731-4. Epub 2024 Apr 7.
提高下一代测序检测稀有和亚克隆突变的准确性。
Nat Rev Genet. 2018 May;19(5):269-285. doi: 10.1038/nrg.2017.117. Epub 2018 Mar 26.
4
Modernizing Human Cancer Risk Assessment of Therapeutics.将治疗药物的人类癌症风险评估现代化。
Trends Pharmacol Sci. 2018 Mar;39(3):232-247. doi: 10.1016/j.tips.2017.11.005. Epub 2017 Dec 11.
5
Hallmarks of cancer: the next generation.癌症的特征:下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.