Syntheses and Biofilm Reducing Effects of l-Dopa-Derived Analogues of the Fungal Macrocidins A and Z.
作者信息
Pezolt Christine, Karau Annika, Schobert Rainer, Schrey Hedda
机构信息
Organic Chemistry Laboratory, University Bayreuth, Universitaetsstr. 30, 95447, Bayreuth, Germany.
Helmholtz Centre for Infection Research GmbH, Inhoffenstrasse 7, 38124, Braunschweig, Germany.
出版信息
Chemistry. 2023 Apr 13;29(21):e202203647. doi: 10.1002/chem.202203647. Epub 2023 Mar 10.
Four analogues of the fungal metabolites macrocidin A and Z, featuring [13]para- or [13]metacyclophanes, were synthesised from fully and orthogonally protected l-dopa instead of l-tyrosine. They were tested for antibiotic activities and for effects on the growth and persistence of microbial biofilms. Tentative structure-activity relationships and distinct differences when compared with the natural lead compounds were identified.
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