Crawford C D, Butler P, Froese A
Department of Anaesthesia, Queen's University, Kingston, Ontario.
Can J Anaesth. 1987 Sep;34(5):437-41. doi: 10.1007/BF03014344.
The influence of arterial O2 and CO2 tensions on electroconvulsive seizure duration was investigated in five mongrel dogs under consistent anaesthetic conditions. Seizure durations were measured in a randomized protocol of nine possible combinations of arterial gas tension spanning increased, normal or decreased levels of PaO2 and PaCO2. Seizure duration was directly related to PaO2 (p less than 0.00001) and inversely related to PaCO2 (p less than 0.0001). A significant synergism was evident at the extremes of PaO2 and PaCO2, with seizure duration being greater than predicted for hyperoxia-hypocapnia and hypoxia-hypercapnia and shorter than predicted for hypoxia-hypocapnia and hyperoxia-hypercapnia. We conclude that arterial gas tensions strongly influence ECT-induced seizure duration and through this may influence the therapeutic efficacy of electroconvulsive therapy.
在五只因麻醉状态稳定的杂种犬身上，研究了动脉血氧和二氧化碳分压对电惊厥发作持续时间的影响。在一个随机方案中，测定了动脉血气分压九种可能组合下的发作持续时间，这些组合涵盖了动脉血氧分压（PaO₂）和动脉血二氧化碳分压（PaCO₂）升高、正常或降低的水平。发作持续时间与PaO₂呈正相关（p<0.00001），与PaCO₂呈负相关（p<0.0001）。在PaO₂和PaCO₂的极端情况下，明显存在显著协同作用，高氧低碳酸血症和低氧高碳酸血症时的发作持续时间比预测值更长，而低氧低碳酸血症和高氧高碳酸血症时的发作持续时间比预测值更短。我们得出结论，动脉血气分压强烈影响电休克治疗（ECT）诱导的发作持续时间，进而可能影响电惊厥治疗的疗效。
