Genomic Medicine, 61663Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra (INR-LGII), México City, México.
Morphology Department, Escuela Nacional de Ciencias Biológicas, 27740Instituto Politécnico Nacional (ENCB, IPN), México City, México.
Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296221151166. doi: 10.1177/10760296221151166.
Legg-Calvé-Perthes disease (LCPD) is a pediatric disorder that occurs due to the avascular necrosis of the femoral head and affects the range of motion of the hip in various degrees. Its etiology is still unknown, although it has been associated with coagulation abnormalities, however, the lack of reproducibility in the results in various studies has created a controversy as to whether hemostasis disorders are related to LCPD. On the other hand, there is little information on laboratory studies that could facilitate the diagnosis and treatment of LCPD.
Blood and plasma samples were tested from 25 patients with LCPD and 50 healthy controls, matched by sex and age. Cellular markers were evaluated through complete blood count, as well as coagulation times, coagulation factors activity, antithrombotic proteins, and homocysteine concentration.
After assessing activity value frequencies in each group, the results showed more significant activity in some of the biological risk markers of thrombophilia, presenting a substantial difference in prothrombin time↘, FV↗, FVIII↗, FIX↗, and Hcy↗. These values imply that there may be hypercoagulable states in patients, which can cause thrombotic events.
Diminished prothrombin time and increase in FV activity, FVIII, FIX, and Hcy concentration support the hypothesis that microthrombi formation in small-caliber vessels could be causing avascularity and femoral necrosis, which are traits of LCPD. In addition, based on our results, we believe that the laboratory studies carried out are very useful in the diagnosis and treatment of LCPD.
Legg-Calvé-Perthes 病（LCPD）是一种儿科疾病，发生于股骨头的缺血性坏死，并以不同程度影响髋关节的运动范围。其病因尚不清楚，尽管它与凝血异常有关，但在各种研究中结果的可重复性缺乏，导致关于止血障碍是否与 LCPD 有关存在争议。另一方面，关于有助于 LCPD 诊断和治疗的实验室研究的信息很少。
从 25 例 LCPD 患者和 50 例性别和年龄匹配的健康对照者中抽取血液和血浆样本。通过全血细胞计数以及凝血时间、凝血因子活性、抗血栓蛋白和同型半胱氨酸浓度评估细胞标志物。
在评估每组的活性值频率后，结果显示一些血栓形成倾向的生物学风险标志物的活性显著增加，凝血酶原时间↘、FV↗、VIII↗、FIX↗和 Hcy↗存在显著差异。这些值表明患者可能存在高凝状态，这可能导致血栓形成事件。
凝血酶原时间降低和 FV 活性、VIII、FIX 和 Hcy 浓度增加支持这样一种假说，即小血管中的微血栓形成可能导致 LCPD 的无血管性和股骨头坏死。此外，基于我们的结果，我们认为进行的实验室研究对于 LCPD 的诊断和治疗非常有用。
