Bone Remodeling and Bone Structural Genes in Legg-Calvé-Perthes Disease: The rs2073618 and rs1800795 Are Associated with High Risk in Mexican Patients.

Legg-Calve-Perthes disease (LCPD) is an idiopathic avascular necrosis of the pediatric femoral head. Bone remodeling and bone structural genes have the potential to contribute to the progression of LCPD when there is disequilibrium between bone resorption and bone formation. A case-control study was performed to search for associations of several common polymorphisms in the genes Receptor Activator for Nuclear Factor κappa B (), Receptor Activator for Nuclear Factor κappa B Ligand (), osteoprotegerin (), interleukin ()-, and type 1 collagen () with LCPD susceptibility in Mexican children. A total of 23 children with LCPD and 46 healthy controls were genotyped for seven polymorphisms (rs3018362, rs12585014, rs2073618, rs1800795, rs1800796, rs1800012, and rs2586498) in the , , , , and genes by real-time polymerase chain reaction with TaqMan probes. The variant allele (C) of rs1800795 was associated with increased risk of LCPD (odds ratio [OR]: 3.8, 95% confidence interval [CI]: [1.08-13.54],  = 0.033), adjusting data by body mass index (BMI) and coagulation factor V (FV), the association with increased risk remained (OR: 4.9, 95% CI: [1.14-21.04],  = 0.025). The polymorphism rs2073618, specifically GC-GG carriers, was associated with a more than fourfold increased risk of developing LCPD (OR: 4.34, 95% CI: [1.04-18.12],  = 0.033) when data were adjusted by BMI-FV. There was no significant association between rs3018362, rs12585014, rs1800796, rs1800012, and rs2586498 polymorphisms and LCPD in a sample of Mexican children. The rs1800975 and rs2037618 polymorphisms in the and genes, respectively, are informative markers of increased risk of LCPD in Mexican children.