Department of Pulmonology, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey.
Department of Pulmonology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
Arch Endocrinol Metab. 2023 Mar 30;67(3):341-347. doi: 10.20945/2359-3997000000544. Epub 2023 Jan 17.
Various studies have shown that diabetes mellitus (DM) increases the risk of thrombosis in the venous system as well as in the arterial system. In this study, it was aimed to evaluate the association between admission blood glucose levels and clinical severity, recurrence, and mortality in pulmonary embolism in patients with DM.
This study was designed as a retrospective cross-sectional study. Patients with DM who were admitted to a tertiary care hospital due to pulmonary embolism (PE) between 2014 and 2019 were included. Demographic characteristics, radiological findings, clinical class of embolism, and mortality data were retrieved from hospital records. Patients with and without recurrent disease, as well as patients who survived and died, were compared. Also, patients were classified according to quartiles of admission blood glucose levels. The quartiles were compared in terms of mortality, clinical, class, and recurrence.
Two hundred ninety-three patients with DM and PE were included in the study. Patients with adverse outcome had significantly higher admission blood glucose levels (respectively, 197.9 ± 96.30 mg/dL 170.7 ± 74.26 mg/dL; p = 0.03). Patients in the third and fourth quartile of admission blood glucose levels (>152 mg/ dL) had significantly more severe disease with a higher proportion of massive and sub-massive PE and higher pro-BNP levels (respectively, p = 0.01 and 0.02).
Non-survived patients and recurrent disease were associated with higher admission blood glucose levels. Also, patients with admission blood glucose levels higher than 152 mg/dL tend to have clinically more severe diseases.
多项研究表明，糖尿病（DM）会增加静脉系统和动脉系统发生血栓的风险。本研究旨在评估入院时血糖水平与糖尿病合并肺栓塞患者的临床严重程度、复发和死亡率之间的关系。
本研究设计为回顾性横断面研究。纳入 2014 年至 2019 年间因肺栓塞（PE）入住三级护理医院的 DM 患者。从医院记录中检索人口统计学特征、影像学发现、栓塞临床分级和死亡率数据。比较有和无复发疾病、存活和死亡的患者。此外，根据入院时血糖水平的四分位数对患者进行分类。比较死亡率、临床、分级和复发情况。
本研究纳入 293 例 DM 合并 PE 患者。不良结局患者的入院血糖水平显著升高（分别为 197.9±96.30 mg/dL 170.7±74.26 mg/dL；p=0.03）。入院血糖水平处于第三和第四四分位数（>152 mg/dL）的患者疾病更严重，大/次大面积 PE 比例更高，Pro-BNP 水平更高（分别为 p=0.01 和 0.02）。
未存活患者和复发疾病与更高的入院血糖水平相关。此外，入院血糖水平高于 152 mg/dL 的患者临床疾病更严重。
