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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gordon R D, Bachmann A W, Gueizelar B, Dai Y

Endocrine-Hypertension Research Unit, University of Queensland, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):163-7. doi: 10.1111/j.1440-1681.1987.tb00369.x.

In normal subjects and essential hypertensives, plasma noradrenaline (NA) levels, and NA clearance (3H-NA constant infusion), were measured during graded infusion of NA. 2. Plasma levels of NA were similar in both groups, with parallel increases to levels approximately three times basal, but still in the upper normal range. 3. Clearance did not increase in either group with increasing plasma NA levels. There was no correlation between plasma NA achieved and NA clearance, which was similar in hypertensives and normotensives. 5. Insofar as plasma clearance reflects tissue clearance, these studies provide no support for the contention that altered NA metabolism might predispose to elevated NA levels in essential hypertension.

在正常受试者和原发性高血压患者中，在去甲肾上腺素（NA）分级输注期间测量了血浆去甲肾上腺素（NA）水平和NA清除率（3H-NA持续输注）。2. 两组的血浆NA水平相似，均平行升高至约为基础水平三倍的水平，但仍处于正常范围上限。3. 两组的清除率均未随血浆NA水平升高而增加。所达到的血浆NA水平与NA清除率之间无相关性，高血压患者和血压正常者的NA清除率相似。5. 就血浆清除率反映组织清除率而言，这些研究不支持下述观点，即去甲肾上腺素代谢改变可能是原发性高血压中去甲肾上腺素水平升高的诱因。

Gordon R D, Bachmann A W, Gueizelar B, Dai Y

Endocrine-Hypertension Research Unit, University of Queensland, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):163-7. doi: 10.1111/j.1440-1681.1987.tb00369.x.

In normal subjects and essential hypertensives, plasma noradrenaline (NA) levels, and NA clearance (3H-NA constant infusion), were measured during graded infusion of NA. 2. Plasma levels of NA were similar in both groups, with parallel increases to levels approximately three times basal, but still in the upper normal range. 3. Clearance did not increase in either group with increasing plasma NA levels. There was no correlation between plasma NA achieved and NA clearance, which was similar in hypertensives and normotensives. 5. Insofar as plasma clearance reflects tissue clearance, these studies provide no support for the contention that altered NA metabolism might predispose to elevated NA levels in essential hypertension.

在正常受试者和原发性高血压患者中，在去甲肾上腺素（NA）分级输注期间测量了血浆去甲肾上腺素（NA）水平和NA清除率（3H-NA持续输注）。2. 两组的血浆NA水平相似，均平行升高至约为基础水平三倍的水平，但仍处于正常范围上限。3. 两组的清除率均未随血浆NA水平升高而增加。所达到的血浆NA水平与NA清除率之间无相关性，高血压患者和血压正常者的NA清除率相似。5. 就血浆清除率反映组织清除率而言，这些研究不支持下述观点，即去甲肾上腺素代谢改变可能是原发性高血压中去甲肾上腺素水平升高的诱因。