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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wintour E M, Coghlan J P, Congiu M, Grim C E, Laurence B M, Meehan P J, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Apr;14(4):319-26. doi: 10.1111/j.1440-1681.1987.tb00977.x.

In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged. 2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 micrograms/h, into water-loaded and sodium-depleted ewes, either non-pregnant or during the last third of gestation. 3. In the water-loaded state, MAP rose significantly at the lowest rate of infusion in both pregnant and non-pregnant ewes. Bradycardia occurred first at 0.3 micrograms/h in the pregnant ewes but not until 3.0 micrograms/h in the non-pregnant animals. 4. In sodium deficiency there was no increase in MAP at any rate of infusion in either group. Bradycardia occurred in both groups at 1 microgram/h. 5. This study shows that the pressor effects of AVP are unchanged by pregnancy. However, pregnant ewes are more sensitive to AVP-induced bradycardia when the ewes are water-loaded.

在清醒的母羊中，怀孕与心率和心输出量显著增加有关，而平均动脉压（MAP）和每搏输出量未发生变化。2. 本研究考察了以0.3、1、3.0和10微克/小时的速率向非怀孕或妊娠晚期的水负荷和缺钠母羊输注精氨酸加压素（AVP）的效果。3. 在水负荷状态下，怀孕和非怀孕母羊在最低输注速率时MAP均显著升高。怀孕母羊在输注速率为0.3微克/小时时首先出现心动过缓，而非怀孕动物直到输注速率为3.0微克/小时时才出现。4. 在缺钠情况下，两组在任何输注速率下MAP均未升高。两组在输注速率为1微克/小时时均出现心动过缓。5. 本研究表明，AVP的升压作用不受怀孕影响。然而，当母羊处于水负荷状态时，怀孕母羊对AVP诱导的心动过缓更敏感。

Wintour E M, Coghlan J P, Congiu M, Grim C E, Laurence B M, Meehan P J, McDougall J G, Scoggins B A

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Apr;14(4):319-26. doi: 10.1111/j.1440-1681.1987.tb00977.x.

In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged. 2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 micrograms/h, into water-loaded and sodium-depleted ewes, either non-pregnant or during the last third of gestation. 3. In the water-loaded state, MAP rose significantly at the lowest rate of infusion in both pregnant and non-pregnant ewes. Bradycardia occurred first at 0.3 micrograms/h in the pregnant ewes but not until 3.0 micrograms/h in the non-pregnant animals. 4. In sodium deficiency there was no increase in MAP at any rate of infusion in either group. Bradycardia occurred in both groups at 1 microgram/h. 5. This study shows that the pressor effects of AVP are unchanged by pregnancy. However, pregnant ewes are more sensitive to AVP-induced bradycardia when the ewes are water-loaded.

在清醒的母羊中，怀孕与心率和心输出量显著增加有关，而平均动脉压（MAP）和每搏输出量未发生变化。2. 本研究考察了以0.3、1、3.0和10微克/小时的速率向非怀孕或妊娠晚期的水负荷和缺钠母羊输注精氨酸加压素（AVP）的效果。3. 在水负荷状态下，怀孕和非怀孕母羊在最低输注速率时MAP均显著升高。怀孕母羊在输注速率为0.3微克/小时时首先出现心动过缓，而非怀孕动物直到输注速率为3.0微克/小时时才出现。4. 在缺钠情况下，两组在任何输注速率下MAP均未升高。两组在输注速率为1微克/小时时均出现心动过缓。5. 本研究表明，AVP的升压作用不受怀孕影响。然而，当母羊处于水负荷状态时，怀孕母羊对AVP诱导的心动过缓更敏感。