促肾上腺皮质激素给药对绵羊精氨酸加压素血流动力学反应的影响。
Effect of ACTH administration on the haemodynamic response to arginine-vasopressin in sheep.
作者信息
Coghlan J P, Denton D A, Graham W F, Humphrey T J, Mason R T, Schnieder E G, Scoggins B A, Whitworth J A
出版信息
Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):559-62. doi: 10.1111/j.1440-1681.1980.tb00111.x.
Abstract
- Blood pressure, heart rate and cardiac output were studies in intace conscious sheep during AVP infusion at 0.1, 0.25, 0.5 and 1.0 microgram/min for 30 minutes to determine whether pressor responsiveness to AVP was altered in ACTH-induced hypertension. 2. Prior to ACTH treatment, AVP produced rises in blood pressure associated with a fall in heart rate and cardiac output. 3. During ACTH treatment, pressor responsiveness to AVP and decrease in cardiac output were unchanged, but reflex bradycardia was reduced. 4. ACTH-induced hypertension in sheep is not associated with enhanced pressor responsiveness to AVP.
摘要
- 对清醒绵羊静脉输注血管加压素（AVP），剂量分别为0.1、0.25、0.5和1.0微克/分钟，持续30分钟，期间监测血压、心率和心输出量，以确定促肾上腺皮质激素（ACTH）诱导的高血压是否改变了对AVP的升压反应性。2. 在ACTH治疗前，AVP使血压升高，同时心率和心输出量下降。3. 在ACTH治疗期间，对AVP的升压反应性和心输出量的降低没有变化，但反射性心动过缓有所减轻。4. 绵羊中ACTH诱导的高血压与对AVP的升压反应性增强无关。
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