Ho Jien Sze, Wong Jie Jun, Gao Fei, Wee Hai Ning, Teo Louis L Y, Ewe See Hooi, Tan Ru-San, Ching Jianhong, Chua Kee Voon, Lee Lye Siang, Koh Woon-Puay, Kovalik Jean-Paul, Koh Angela S
National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
Duke-NUS Medical School, Singapore, Singapore.
Clin Res Cardiol. 2023 Nov;112(11):1555-1567. doi: 10.1007/s00392-023-02156-w. Epub 2023 Jan 18.
Despite known sex-based differences in cardiovascular aging, differences in aging biology are poorly understood. We hypothesize that circulating metabolites studied cross-sectionally with cardiac aging may be associated with cardiovascular changes that distinguish cardiac aging in women.
A population-based cohort of community men and women without cardiovascular disease from Singapore underwent detailed clinical and echocardiography examinations. Cross-sectional associations between cardiac functional characteristics and metabolomics profiles were examined.
Five hundred sixty-seven adults (48.9% women) participated. Women were younger (72 ± 4.4 years vs 73 ± 4.3 years, p = 0.022), had lower diastolic blood pressures (71 ± 11.0 mmHg vs 76 ± 11.2 mmHg, p < 0.0001, and less likely to have diabetes mellitus (18.0% vs 27.6%, p = 0.013) and smoking (3.8% vs 34.5%, p < 0.001). Body mass indices were similar (24 ± 3.8 kg/m vs 24 ± 3.4 kg/m, p = 0.29), but women had smaller waist circumferences (81 ± 10.1 cm vs 85 ± 9.2 cm, p < 0.001). Women had a significantly higher E/e' ratios (10.9 ± 3.4 vs 9.9 ± 3.3, p = 0.007) and mitral A peak (0.86 ± 0.2 m/s vs 0.79 ± 0.2 m/s, p < 0.001) than men. Among women, lower E/e' ratio was associated with higher levels of C16 (OR 1.019, 95%CI 1.002-1.036, p = 0.029), C16:1 (OR 1.06, 95%CI 1.006-1.118, p = 0.028), serine (OR 1.019, 95%CI 1.002-1.036, p = 0.025), and histidine (OR 1.045, 95%CI 1.013-1.078, p = 0.006). Lower mitral A peak was associated with higher levels of histidine (OR 1.039, 95%CI 1.009-1.070, p = 0.011), isoleucine (OR 1.013, 95%CI 1.004-1.021, p = 0.004), and C20 (OR 1.341, 95%CI 1.067-1.684, p = 0.012).
Impairments in diastolic functions were more frequent among older women compared to men, despite lower prevalence of vascular risk factors and preserved cardiac structure. Cardiac aging in women correlated with metabolites involved in fatty acid oxidation and tricyclic acid cycle fuelling.
尽管已知心血管衰老存在基于性别的差异，但对衰老生物学差异的了解却很少。我们假设，与心脏衰老进行横断面研究的循环代谢物可能与区分女性心脏衰老的心血管变化有关。
来自新加坡的一个基于人群的无心血管疾病的社区男性和女性队列接受了详细的临床和超声心动图检查。检查了心脏功能特征与代谢组学谱之间的横断面关联。
567名成年人（48.9%为女性）参与了研究。女性更年轻（72±4.4岁对73±4.3岁，p=0.022），舒张压更低（71±11.0mmHg对76±11.2mmHg，p<0.0001），患糖尿病的可能性更小（18.0%对27.6%，p=0.013），吸烟的可能性更小（3.8%对34.5%，p<0.0０1）。体重指数相似（24±3.8kg/m对24±3.4kg/m，p=0.29），但女性腰围更小（81±10.1cm对85±9.2cm，p<0.001）。女性的E/e'比值（10.9±3.4对9.9±3.3，p=0.007）和二尖瓣A峰（0.86±0.2m/s对0.79±0.2m/s，p<0.001）明显高于男性。在女性中，较低的E/e'比值与较高水平的C16（OR 1.019，95%CI 1.002-1.036，p=0.029）、C16:1（OR 1.06，95%CI 1.006-1.118，p=0.028）、丝氨酸（OR 1.019，95%CI 1.002-1.036，p=0.025）和组氨酸（OR 1.045，95%CI 1.013-1.078，p=0.006）有关。较低的二尖瓣A峰与较高水平的组氨酸（OR 1.039，95%CI 1.009-1.070，p=0.011）、异亮氨酸（OR 1.013，95%CI 1.004-1.021，p=0.004）和C20（OR 1.341，95%CI 1.067-1.684，p=0.012）有关。
尽管血管危险因素的患病率较低且心脏结构保持正常，但老年女性舒张功能障碍比男性更常见。女性心脏衰老与参与脂肪酸氧化和三羧酸循环供能的代谢物有关。
