老年女性的升主动脉应变与心室动脉耦合与弗明汉10年风险呈中度相关。

Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk.

作者信息

Wong Jie Jun, Zhang Hongzhou, Leng Shuang, Gao Fei, Zhao Xiaodan, Tan Kieran, Tan Ru-San, Zhong Liang, Koh Angela S

机构信息

Department of Cardiology, National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore, Singapore.

Department of Cardiovascular Medicine, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.

出版信息

Eur Heart J Imaging Methods Pract. 2025 Jun 4;3(1):qyaf075. doi: 10.1093/ehjimp/qyaf075. eCollection 2025 Jan.

DOI:10.1093/ehjimp/qyaf075

PMID:40584917

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12204193/

Abstract

AIMS

Traditional risk factors do not fully characterize cardiovascular aging and are less helpful in assessing sex differences in cardiovascular risk. Using a novel cardiovascular magnetic resonance (CMR) method, we determined sex differences in aortic global longitudinal strain (AOGLS) and ventriculoarterial coupling (VAC) with correlations to Framingham risk scores.

METHODS AND RESULTS

Community older adults without cardiovascular disease underwent CMR. AOGLS was the maximal absolute Lagrangian strain between the brachiocephalic artery and aortic annulus. VAC was aortic pulse wave velocity (AAPWV) divided by LVGLS. Among 202 participants (46.0% female, 70.2 ± 8.8 years), women had lower diastolic blood pressure (DBP) (70.5 ± 10.8 mmHg vs. 78.1 ± 9.5 mmHg, < 0.001), body surface area (BSA) (1.52 ± 0.12 m vs. 1.70 ± 0.14 m, < 0.001), and fewer smokers (3.2% vs. 25.7% < 0.001) than men, despite similar ages. Women had better AAPWV (8.41 ± 2.73 m/s vs. 9.13 ± 3.18 m/s, adj. = 0.020), AOGLS (6.16 ± 2.44% vs. 5.21 ± 1.74%, adj. = 0.030), LVGLS (-21.93 ± 2.59 vs. -20.06 ± 2.79%, adj. = 0.021), VAC (-0.39 ± 0.15 vs. -0.47 ± 0.21, adj. = 0.006), and smaller indexed cardiac volumes. Female sex was associated with better AOGLS ( = 0.838, adj. = 0.030; = 0.103) and VAC ( = -0.093, adj. = 0.006; = 0.113) independent of smoking, DBP, and BSA. Among women, AOGLS was moderately correlated with 10-year risks ( = -0.400 = <0.001) and VAC was associated with 10-year risks ( = -6.915, adj. = 0.017; = 0.145).

CONCLUSION

Novel CMR-derived aortic longitudinal strain differentiated ventriculo-aortic aging between the sexes. Women had superior AOGLS and VAC, independent of body size and DBP, that correlated better with Framingham risk scores compared to men. Impaired AOGLS and VAC may be useful in differentiating individuals at intermediate from low-borderline cardiovascular risk. : ClinicalTrials.gov Identifier: NCT02791139.

摘要

目的

传统风险因素不能完全描述心血管衰老情况，在评估心血管风险的性别差异方面作用较小。我们使用一种新型心血管磁共振（CMR）方法，确定主动脉整体纵向应变（AOGLS）和心室动脉耦联（VAC）的性别差异及其与弗雷明汉风险评分的相关性。

方法与结果

无心血管疾病的社区老年人接受CMR检查。AOGLS是头臂动脉与主动脉瓣环之间的最大绝对拉格朗日应变。VAC是主动脉脉搏波速度（AAPWV）除以左心室整体纵向应变（LVGLS）。在202名参与者中（46.0%为女性，年龄70.2±8.8岁），尽管年龄相似，但女性的舒张压（DBP）较低（70.5±10.8 mmHg对78.1±9.5 mmHg，P<0.001）、体表面积（BSA）较小（1.52±0.12 m²对1.70±0.14 m²，P<0.001），吸烟者较少（3.2%对25.7%，P<0.001）。女性的AAPWV更好（8.41±2.73 m/s对9.13±3.18 m/s，校正P=0.020）、AOGLS更好（6.16±2.44%对5.21±1.74%，校正P=0.030）、LVGLS更好（-21.93±2.59对-20.06±2.79%，校正P=0.021）、VAC更好（-0.39±0.15对-0.47±0.21，校正P=0.006），且心脏指数体积较小。女性性别与更好的AOGLS（β=0.838，校正P=0.030；R²=0.103）和VAC（β=-0.093，校正P=0.006；R²=0.113）独立相关，与吸烟、DBP和BSA无关。在女性中，AOGLS与10年风险中度相关（β=-0.400，P<0.001），VAC与10年风险相关（β=-6.915，校正P=0.017；R²=0.145）。