Li Yanhui, Hua Cuiju, Zhang Mengyao
Department of Obstetrics and Gynecology, Shandong University Qilu Hospital, 107 Wenhua West Road, Lixia District, Jinan City, Shandong Province, China.
Yiyuan People's Hospital, Zibo City, Shandong Province, China.
Lasers Med Sci. 2023 Jan 18;38(1):42. doi: 10.1007/s10103-023-03713-5.
Photodynamic therapy (PDT) is a proposed non-invasive, highly effective, and fertility-preserving method for the treatment of lower reproductive tract diseases in women. We aim to evaluate the effect of PDT on complete remission, recurrence, and HPV clearance in diseases of the female lower reproductive tract associated with the human papillomavirus (HPV) infection in this meta-analysis. PubMed, EMBASE, Scopus, Cochrane Library, and China National Knowledge Infrastructure databases were searched to compare PDT with other treatments for complete remission, recurrence, and HPV clearance in women with lower genital tract disease. Fixed or random effect models were performed to assess the pooled effect size. Sensitivity analysis was performed to detect heterogeneity in the included studies. The Begg and Egger test assessed publication bias. There were 12 studies qualified for inclusion; compared to other treatments, PDT had a significant advantage in complete remission (OR=2.97, 95%CI, 2.18-4.04, I=0, P<0. 001) and recurrence (OR, 0.21; 95%CI, 0.11-0.39; I=34.9%, P<0. 001). Furthermore, PDT clears HPV quickly and lastingly compared to other therapies (OR, 2.65; 95% CI, 1.41-4.95; I=71.0%, P=0.002). In addition, the heterogeneity test of sensitivity analysis suggested that the results were robust. Begg test (P=0.73) and Egger test (P=0.71) showed no publication bias. PDT treats diseases of the female lower reproductive tract associated with HPV infection: high complete remission, low recurrence, and rapid and lasting HPV clearance. The PDT seems to be a non-invasive, effective, and promising treatment of female lower reproductive tract diseases associated with HPV infection.
光动力疗法（PDT）是一种用于治疗女性下生殖道疾病的非侵入性、高效且能保留生育能力的方法。在这项荟萃分析中，我们旨在评估光动力疗法对与人类乳头瘤病毒（HPV）感染相关的女性下生殖道疾病的完全缓解、复发及HPV清除情况的影响。检索了PubMed、EMBASE、Scopus、Cochrane图书馆和中国知网数据库，以比较光动力疗法与其他治疗方法对下生殖道疾病女性的完全缓解、复发及HPV清除情况。采用固定效应或随机效应模型评估合并效应量。进行敏感性分析以检测纳入研究中的异质性。采用Begg和Egger检验评估发表偏倚。有12项研究符合纳入标准；与其他治疗方法相比，光动力疗法在完全缓解（OR=2.97，95%CI，2.18 - 4.04，I=0，P<0.001）和复发（OR，0.21；95%CI，0.11 - 0.39；I=34.9%，P<0.001）方面具有显著优势。此外，与其他疗法相比，光动力疗法能快速且持久地清除HPV（OR，2.65；95%CI，1.41 - 4.95；I=71.0%，P=0.002）。此外敏感性分析的异质性检验表明结果具有稳健性。Begg检验（P=0.73）和Egger检验（P=0.71）显示无发表偏倚。光动力疗法治疗与HPV感染相关的女性下生殖道疾病：完全缓解率高、复发率低且能快速持久地清除HPV。光动力疗法似乎是一种治疗与HPV感染相关的女性下生殖道疾病的非侵入性、有效且有前景的治疗方法。
