School of Public Health and Management, Ningxia Medical University, Ningxia, 750004, China.
Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia, 750004, China.
Endocr J. 2023 Apr 28;70(4):427-434. doi: 10.1507/endocrj.EJ22-0462. Epub 2023 Jan 18.
Data regarding different metabolic phenotypes and bone markers including bone mineral content (BMC) and osteocalcin (OCN) among children and adolescents are very limited. Hence, the purpose of this investigation was to explore the relationship between different metabolic phenotypes and BMC or OCN among Chinese children and adolescents. This cross-sectional study included 1,328 children and adolescents aged between 12 and 18 years who were selected from four schools in Yinchuan city from 2018 to 2020 by stratified cluster random sampling. Subjects were divided into four groups according to BMI and metabolic status, as follows: metabolically healthy obesity (MHO), metabolically unhealthy obesity (MUO), metabolically unhealthy normal weight (MUNW), and metabolically healthy normal weight (MHNW). The MHNW, MUNW, MHO, and MUO phenotypes in boys were 48.4%, 30.5%, 6.7%, and 14.4%, respectively, and were 47.8%, 33.6%, 6.6%, and 12.1% in girls, respectively. The MHO and MUO phenotypes had higher BMC than the MHNW or MUNW phenotype (all p < 0.05), and the MUO phenotype with BMC was significantly higher than MHO group in boys (p < 0.05). We discovered a significant positive correlation between BMC and the MHO (OR = 8.82, 95% CI = 2.04-38.16), MUO phenotypes (OR = 13.53, 95% CI = 4.10-44.70), while no association was found between OCN and metabolic phenotypes in neither boys nor girls. Overweight/obese children and adolescents had higher BMC, and there existed sex differences in the effect of metabolic status on BMC among them. OCN was not supposed to be an index of bone health in this study.
关于儿童和青少年不同代谢表型和骨标志物（包括骨矿物质含量（BMC）和骨钙素（OCN））的数据非常有限。因此，本研究旨在探讨中国儿童和青少年不同代谢表型与 BMC 或 OCN 之间的关系。本横断面研究纳入了 2018 年至 2020 年期间通过分层整群随机抽样从银川市四所学校中选择的 1328 名 12 至 18 岁的儿童和青少年。根据 BMI 和代谢状态，将受试者分为 4 组：代谢健康肥胖（MHO）、代谢不健康肥胖（MUO）、代谢不健康正常体重（MUNW）和代谢健康正常体重（MHNW）。男孩中的 MHNW、MUNW、MHO 和 MUO 表型分别为 48.4%、30.5%、6.7%和 14.4%，女孩中分别为 47.8%、33.6%、6.6%和 12.1%。MHO 和 MUO 表型的 BMC 高于 MHNW 或 MUNW 表型（均 P<0.05），且 MUO 表型的 BMC 明显高于男孩中的 MHO 组（P<0.05）。我们发现 BMC 与 MHO（OR=8.82，95%CI=2.04-38.16）和 MUO 表型（OR=13.53，95%CI=4.10-44.70）之间存在显著正相关，而在男孩和女孩中，OCN 与代谢表型之间均无关联。超重/肥胖儿童和青少年的 BMC 较高，且代谢状态对 BMC 的影响在男孩和女孩中存在性别差异。在本研究中，OCN 不应作为骨健康的指标。
