Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Sci Rep. 2023 Jan 18;13(1):1007. doi: 10.1038/s41598-023-28284-x.
In this study, Se-doped FeO with antibacterial properties was synthesized using by a coprecipitation method. The chemistry and morphology of the Se doped FeO nanocomposite were characterized by energy-dispersive X-ray spectroscopy, field-emission scanning electron microscopy, X-ray diffraction, vibrating sample magnetometry, and Brunauer-Emmett-Teller spectroscopy. The antibacterial activity of the FeO/Se nanocomposite was examined against G (Gram-positive) and G (Gram-negative) bacteria, in the order Staphylococcus aureus, Staphylococcus saprophyticus, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli, which are the most harmful and dangerous bacteria. FeO/Se, as a heterogeneous catalyst, was successfully applied to the synthesis of pyrazolopyridine and its derivatives via a one-pot four-component reaction of ethyl acetoacetate, hydrazine hydrate, ammonium acetate, and various aromatic aldehydes. FeO/Se was easily separated from the bacteria-containing solution using a magnet. Its admissible magnetic properties, crystalline structure, antibacterial activity, mild reaction conditions, and green synthesis are specific features that have led to the recommendation of the use of FeO/Se in the water treatment field and medical applications. Direct Se doping of FeO was successfully realized without additional complicated procedures.
在这项研究中，使用共沉淀法合成了具有抗菌性能的硒掺杂 FeO。通过能量色散 X 射线光谱、场发射扫描电子显微镜、X 射线衍射、振动样品磁强计和 Brunauer-Emmett-Teller 光谱对硒掺杂 FeO 纳米复合材料的化学和形态进行了表征。FeO/Se 纳米复合材料对 G（革兰氏阳性）和 G（革兰氏阴性）细菌的抗菌活性进行了研究，顺序为金黄色葡萄球菌、腐生葡萄球菌、铜绿假单胞菌、肺炎克雷伯菌和大肠杆菌，它们是最有害和最危险的细菌。FeO/Se 作为多相催化剂，成功地应用于通过一锅四组分反应，由乙酰乙酸乙酯、水合肼、醋酸铵和各种芳香醛合成吡唑并吡啶及其衍生物。FeO/Se 可以很容易地用磁铁从含菌溶液中分离出来。其允许的磁性、晶体结构、抗菌活性、温和的反应条件和绿色合成是推荐在水处理领域和医学应用中使用 FeO/Se 的具体特点。直接对 FeO 进行硒掺杂，无需额外的复杂程序。
