Unidad de Bacteriología y Micobacterias, Corporación para Investigaciones Biológicas, Universidad Pontificia Bolivariana, Medellín, Colombia.
Grupo de Investigación en Salud Familiar y Comunitaria, School of Health Sciences, Corporación Universitaria Remington, Medellín, Colombia.
BMC Pediatr. 2023 Jan 19;23(1):28. doi: 10.1186/s12887-022-03798-x.
Childhood tuberculosis continues to be a major public health problem. Although the visibility of the epidemic in this population group has increased, further research is needed.
To design, implement and evaluate an integrated care strategy for children under five years old who are household contacts of bacteriologically confirmed pulmonary tuberculosis patients in Medellín and the Metropolitan Area.
A quasi-experimental study in which approximately 300 children who are household contacts of bacteriologically confirmed pulmonary tuberculosis patients from Medellín and the Metropolitan Area will be evaluated and recruited over one year. A subgroup of these children, estimated at 85, who require treatment for latent tuberculosis, will receive an integrated care strategy that includes: some modifications of the current standardized scheme in Colombia, with rifampicin treatment daily for four months, follow-up under the project scheme with nursing personnel, general practitioners, specialists, professionals from other disciplines such as social work, psychology, and nutritionist. Additionally, transportation and food assistance will be provided to encourage treatment compliance. This strategy will be compared with isoniazid treatment received by a cohort of children between 2015 and 2018 following the standardized scheme in the country. The study was approved by the CIB Research Ethics Committee and UPB.
gov identifier NCT04331262.
This study is expected to contribute to the development of integrated care strategies for the treatment of latent tuberculosis in children. The results will have a direct impact on the management of childhood tuberculosis contributing to achieving the goals proposed by the World Health Organization's End TB Strategy.
ClinicalTrials.gov identifier NCT04331262 . Implementation of an Integrated Care Strategy for Children Contacts of Patients with Tuberculosis. Registered 2 April 2020.
儿童结核病仍然是一个主要的公共卫生问题。尽管该人群中的疫情可见度有所提高，但仍需要进一步研究。
设计、实施和评估一种针对在麦德林和大都市区与确诊菌阳肺结核患者有家庭接触的五岁以下儿童的综合护理策略。
这是一项准实验研究，在一年多的时间里，将评估和招募大约 300 名来自麦德林和大都市区的与确诊菌阳肺结核患者有家庭接触的儿童。其中，估计有 85 名需要接受潜伏性结核病治疗的儿童将接受综合护理策略，包括：对哥伦比亚现行标准化方案的一些修改，每日服用利福平治疗四个月，按照项目方案由护士、全科医生、专科医生、来自社会工作、心理学和营养学家等其他学科的专业人员进行随访。此外，还将提供交通和食品援助，以鼓励治疗依从性。该策略将与 2015 年至 2018 年期间根据该国标准化方案接受异烟肼治疗的儿童队列进行比较。该研究已获得 CIB 研究伦理委员会和 UPB 的批准。
gov 标识符 NCT04331262。
本研究有望为儿童潜伏性结核病的综合护理策略的制定做出贡献。研究结果将直接影响儿童结核病的管理，有助于实现世界卫生组织终止结核病战略提出的目标。
ClinicalTrials.gov 标识符 NCT04331262。实施针对结核病患者接触者的儿童综合护理策略。注册于 2020 年 4 月 2 日。
