Mohammed Nasreldin, Kamel Mostafa, Gadelkareem Rabea Ahmed, Zarzour Mohammed Ali, Kurkar Adel, Abdel-Moniem Ahmed Mohammed, Behnsawy Hosny
Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut, Egypt.
Basic Clin Androl. 2023 Jan 19;33(1):2. doi: 10.1186/s12610-022-00175-7.
Despite the documented effects of the coronavirus disease 2019 (COVID-19) on spermatogenesis, the reversibility of these effects is uncertain. We aimed to assess the changes of sperm quality between the infection and recovery phases of COVID-19 in reproductive-aged men. The semen quality of men with mild-to-moderated COVID-19 (defined by the degrees of symptoms and chest involvement on computed tomography) was studied during October, 2020-May, 2021 at our hospital. Two semen samples were analyzed at timings estimated to represent spermatogenic cycles during the infection and recovery phases of COVID-19.
A total of 100 patients were included with mean ± SD (range) age of 24.6 ± 3.3 (21-35) years. During infection, 33% of patients had abnormal semen quality. However, a significant reduction was found in this abnormality from 33 to 11% (P < 0.001) after recovery from infection. In a comparison of the two semen analyses, there were significant improvements in the mean values of sperm progressive motility (P =0.043) and normal morphology (P < 0.001). However, the mean sperm concentration showed a statistically insignificant increase (P = 0.844).
In reproductive-aged patients with mild-to-moderate COVID-19, the effects on seminal quality were recoverable, represented by significant improvements in the means of progressive sperm motility and normal morphology between the infection and recovery phases of COVID-19.
ClinicalTrials, NCT04595240 .
尽管有文献记载2019冠状病毒病（COVID-19）对精子发生有影响，但这些影响的可逆性尚不确定。我们旨在评估COVID-19感染期和恢复期之间生殖年龄男性精子质量的变化。2020年10月至2021年5月在我院对轻度至中度COVID-19患者（根据症状程度和计算机断层扫描显示的肺部受累情况定义）的精液质量进行了研究。在估计代表COVID-19感染期和恢复期精子发生周期的时间点分析了两份精液样本。
共纳入100例患者，平均年龄±标准差（范围）为24.6±3.3（21 - 35）岁。在感染期间，33%的患者精液质量异常。然而，感染恢复后，这种异常情况从33%显著降至11%（P < 0.001）。在两次精液分析的比较中，精子前向运动平均值（P = 0.043）和正常形态（P < 0.001）有显著改善。然而，平均精子浓度虽有增加，但差异无统计学意义（P = 0.844）。
在轻度至中度COVID-19的生殖年龄患者中，对精液质量的影响是可恢复的，表现为COVID-19感染期和恢复期之间精子前向运动平均值和正常形态有显著改善。
ClinicalTrials，NCT04595240 。
