Sengupta Pallav, Dutta Sulagna, Roychoudhury Shubhadeep, D'Souza Urban John Arnold, Govindasamy Kadirvel, Kolesarova Adriana
Physiology Unit, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Chennai 600126, India.
Antioxidants (Basel). 2022 Mar 14;11(3):548. doi: 10.3390/antiox11030548.
Coronavirus disease 2019 (COVID-19) involves a complex pathogenesis and with the evolving novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the long-term impacts of the unceasing COVID-19 pandemic are mostly uncertain. Evidence indicates deleterious impact of this disease upon male reproductive health. It is concerning that COVID-19 may contribute to the already global declining trend of male fertility. The adverse impacts of COVID-19 on male reproduction may primarily be attributed to the induction of systemic inflammatory responses and oxidative stress (OS), which operate as a vicious loop. Bringing the systemic inflammation to a halt is critical for 'putting out' the 'cytokine storm' induced by excessive reactive oxygen species (ROS) generation. The possibility of OS playing a prime role in COVID-19-mediated male reproductive dysfunctions has led to the advocacy of antioxidant therapy. An array of antioxidant defense medications has shown to be effective in experimental and clinical studies of COVID-19. The present review thus discusses the possibilities as to whether antioxidant drugs would contribute to combating the SARS-CoV-2 infection-induced male reproductive disruptions, thereby aiming at kindling research ideas that are needed for identification and treatment of COVID-19-mediated male reproductive impairments.
2019冠状病毒病（COVID-19）涉及复杂的发病机制，随着严重急性呼吸综合征冠状病毒2（SARS-CoV-2）不断演变的新变种出现，持续的COVID-19大流行的长期影响大多不确定。有证据表明这种疾病对男性生殖健康有有害影响。令人担忧的是，COVID-19可能加剧全球男性生育力已经呈下降趋势的情况。COVID-19对男性生殖的不利影响可能主要归因于全身炎症反应和氧化应激（OS）的诱导，它们形成了一个恶性循环。停止全身炎症对于“扑灭”由过量活性氧（ROS）产生引发的“细胞因子风暴”至关重要。氧化应激在COVID-19介导的男性生殖功能障碍中起主要作用的可能性导致了对抗氧化疗法的倡导。一系列抗氧化防御药物在COVID-19的实验和临床研究中已显示出有效性。因此，本综述讨论了抗氧化药物是否有助于对抗SARS-CoV-2感染引起的男性生殖紊乱的可能性，从而旨在激发识别和治疗COVID-19介导的男性生殖损伤所需的研究思路。
