Yu Chun, Li Donghao, Li Zhongyan, Yu Donghui, Zhai Guijuan
Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103.
Department of Radiology, Affiliated Hospital of Jilin Medical College, JilinChina, 132103.
Acta Pharm. 2020 Dec 31;71(3):473-484. doi: 10.2478/acph-2021-0030. Print 2021 Sep 1.
Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg, ) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg (.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP ( < 0.001). Significant improvements ( < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly ( < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.
我们的研究评估了沙库巴曲缬沙坦（SAC/VAL）在阿霉素诱导的兔心力衰竭模型中的作用。将20只兔子（每组5只）给予阿霉素（DOX，1.5mg/kg）以诱导心力衰竭。测定了诸如脑钠肽（BNP）、肌钙蛋白T（CnT）、C反应蛋白（CRP）和氧化还原修饰蛋白（ROMs）等特定生物标志物。记录了心脏酶抗氧化系统及其电图特征。与阿霉素组相比，给予5或10mg/kg（.）的SAC/VAL后，心率（HR）、收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）恢复正常，随后肌酐和BNP水平降低（P<0.001）。给予相同剂量的SAC/VAL后，与阿霉素组相比，过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和脂质过氧化物（LPO）也有显著改善（P<0.05）。与基线值相比，治疗后诸如BNP、CnT、CRP和ROMs等特定生物标志物显著下降（P<0.001）。我们的研究结果表明，SAC/VAL治疗可减轻炎症和氧化应激，从而改善心脏功能。
