Chrustek Agnieszka, Olszewska-Słonina Dorota
Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, L. Rydygier Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
Acta Pharm. 2020 Dec 31;71(3):335-354. doi: 10.2478/acph-2021-0027. Print 2021 Sep 1.
Melatonin is a hormone that has many body functions and, for several decades, its antioxidant potential has been increasingly talked about. There is a relationship between failure in melatonin production in the pineal gland, an insufficient supply of this hormone to the body, and the occurrence of free radical etiology diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, cancer and others. Despite the development of molecular biology, numerous and studies, the exact mechanism of melatonin antioxidant activity is still unknown. Nowadays, the use of melatonin supplementation is more and more common, not only to prevent insomnia, but also to slow down the aging process and provide protection against diseases. The aim of this study is to get acquainted with current reports on melatonin, antioxidative mechanisms and their importance in diseases of free radical etiology.
褪黑素是一种具有多种身体功能的激素，几十年来，其抗氧化潜力一直备受关注。松果体中褪黑素分泌不足、机体对该激素供应不充分与神经退行性疾病、心血管疾病、糖尿病、癌症等自由基病因疾病的发生之间存在关联。尽管分子生物学不断发展且有大量研究，但褪黑素抗氧化活性的确切机制仍不清楚。如今，补充褪黑素的应用越来越普遍，不仅用于预防失眠，还用于延缓衰老进程以及预防疾病。本研究的目的是了解有关褪黑素、抗氧化机制及其在自由基病因疾病中的重要性的当前报道。
