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先天性胫骨假关节:一篇叙述性综述。

Congenital Pseudoarthrosis of the Tibia: A Narrative Review.

作者信息

Banchhor Hansika, Chimurkar Vilas

机构信息

Department of Medical Education, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.

Department of Anatomy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.

出版信息

Cureus. 2022 Dec 14;14(12):e32501. doi: 10.7759/cureus.32501. eCollection 2022 Dec.

DOI:10.7759/cureus.32501
PMID:36654595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9840411/
Abstract

Congenital pseudoarthrosis of the tibia, also known as CPT, is a rare bone disease mostly occurring in the pediatric age group of 10. The case generally represents anterolateral bowing of the tibia with refractures. This condition is quite rare and has very few cases per year. CPT is still a challenging concern in orthopedics. Bone reunion often requires repeated surgical measurements. With advancements, we have new treatment plans that include induced membrane techniques and bone marrow stromal cell grafts of various induced and morphogenetic protein, which still requires confirmation. Different treatment strategies based on surgical, mechanical, and biological concepts have been shown with varying success rates. Ilizarov technique and vascularised fibular grafts have vastly increased the effectiveness in treating CPT of the tibia. Constant and recurrent refracture, residual deformities, and difficulty obtaining bone union remain the challenges in managing CPT. Hence, phasing CPT as bowing the tibia in an anterolateral fashion is more appropriate because it's a heterogeneous entity with varying prognoses.

摘要

先天性胫骨假关节,也称为CPT,是一种罕见的骨病,主要发生在10岁的儿童年龄组。该病例通常表现为胫骨前外侧弯曲并伴有骨折不愈合。这种情况非常罕见,每年的病例很少。CPT在骨科领域仍然是一个具有挑战性的问题。骨愈合通常需要反复的手术测量。随着技术的进步,我们有了新的治疗方案,包括诱导膜技术和各种诱导和形态发生蛋白的骨髓基质细胞移植,但仍需要进一步证实。基于手术、力学和生物学概念的不同治疗策略已显示出不同的成功率。伊利扎洛夫技术和带血管腓骨移植极大地提高了治疗胫骨CPT的有效性。持续和反复的骨折不愈合、残留畸形以及难以实现骨愈合仍然是管理CPT的挑战。因此,将CPT分期为胫骨前外侧弯曲更为合适,因为它是一个预后不同的异质性实体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5854/9840411/560e99519545/cureus-0014-00000032501-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5854/9840411/5b2a1e9bc26d/cureus-0014-00000032501-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5854/9840411/560e99519545/cureus-0014-00000032501-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5854/9840411/5b2a1e9bc26d/cureus-0014-00000032501-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5854/9840411/560e99519545/cureus-0014-00000032501-i02.jpg

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Curr Rev Musculoskelet Med. 2022 Dec;15(6):438-446. doi: 10.1007/s12178-022-09779-y. Epub 2022 Jul 16.
3
Novel method for the treatment of congenital pseudarthrosis of the tibia using the gastrocnemius flap: A preliminary study.
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2024 Oct 15;38(10):1214-1219. doi: 10.7507/1002-1892.202406056.
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Congenital tibial pseudarthrosis: A challenge in pediatric radiology.先天性胫骨假关节:儿科放射学中的一项挑战。
Radiol Case Rep. 2024 Apr 4;19(6):2502-2507. doi: 10.1016/j.radcr.2024.03.045. eCollection 2024 Jun.
使用腓肠肌皮瓣治疗先天性胫骨假关节的新方法:一项初步研究。
J Child Orthop. 2022 Jun;16(3):167-173. doi: 10.1177/18632521221097525. Epub 2022 Jun 30.
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Are Children Suffering From Congenital Pseudarthrosis of the Tibia Associated With Decreased Bone Strength?患有先天性胫骨假关节的儿童是否伴有骨强度降低?
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