Eisenberg Katherine A, Vuillermin Carley B
Department of Orthopedic Surgery, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
Boston Children's Hospital, 300 Longwood Ave, Boston, MA, USA.
Curr Rev Musculoskelet Med. 2019 Jun 22;12(3):356-368. doi: 10.1007/s12178-019-09566-2.
Congenital pseudoarthrosis of the tibia and fibula are rare conditions that share common treatment strategies. The purpose of this review is to provide an overview of the recent developments in treatments for both conditions.
Recent literature has focused on the use of BMP and on gait analysis as a tool for measuring long-term functional outcomes. Recent study has indicated rhBMP-2 may shorten the time to initial healing of pseudoarthroses, but not guarantee bony union. Children with initial fractures before the age of four have been shown to have long-term gait outcomes that may be ultimately comparable to children with prostheses. Both congenital pseudoarthrosis of the tibia and fibula are challenging conditions to treat, which require comprehensive approaches to account for both the biological and mechanical components of the conditions.
先天性胫腓骨假关节是罕见疾病，有共同的治疗策略。本综述旨在概述这两种疾病治疗的最新进展。
近期文献聚焦于骨形态发生蛋白（BMP）的应用以及将步态分析作为衡量长期功能结局的工具。近期研究表明，重组人骨形态发生蛋白-2（rhBMP-2）可能缩短假关节初始愈合时间，但不能保证骨愈合。已证明4岁前初次骨折的儿童长期步态结局最终可能与接受假体治疗的儿童相当。先天性胫腓骨假关节的治疗均具有挑战性，需要综合考虑疾病的生物学和力学因素。
