Deng Shizhan, Aga Er-Bu, Xie Hongjun, Xiong Hai, Ye Bengui
Medical College of Tibet University Lasa China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University Chengdu China.
Food Sci Nutr. 2022 Sep 25;11(1):434-442. doi: 10.1002/fsn3.3075. eCollection 2023 Jan.
is a well-known traditional medicine in Tibet Autonomous Region, which has benefits, such as anti-hypoxia, neurotrophic action on nerves, easing coughs and relieving asthma, strengthening the body and prolonging life. However, few research have focused on its negative effects, possibly jeopardizing its safety. The purpose of this study is to evaluate the acute and subacute toxicity of an alcoholic extract from (GLA) in vivo. The phytochemical characterization analysis showed that alcoholic extract from were rich in polysaccharides, triterpenoids. Then, in acute oral toxicity, male and female mice from Institute of Cancer Research (ICR) were orally administered with 16 g/kg GLA and were observed for 14 days. In the subacute toxicity, male and female Sprague-Dawley (SD) rats were orally administered with 2, 4, and 8 g/kg doses of GLA for 28 days. There was no death or clinical changes in male and female mice in the acute toxicity test. During the subacute toxicity test, the difference in body weights, food consumption, biochemical and hematological parameters, and organ coefficients between treated and control groups were unrelated to GLA treatment. The obtained data show that the GLA had no significant toxic effects when administered orally to male and female rats in acute and subacute toxicity.
是西藏自治区一种著名的传统药物，具有抗缺氧、对神经的神经营养作用、止咳平喘、强身健体和延年益寿等功效。然而，很少有研究关注其负面影响，这可能会危及它的安全性。本研究的目的是评估（GLA）乙醇提取物在体内的急性和亚急性毒性。植物化学特征分析表明，乙醇提取物富含多糖、三萜类化合物。然后，在急性经口毒性试验中，给癌症研究所（ICR）的雄性和雌性小鼠口服16 g/kg的GLA，并观察14天。在亚急性毒性试验中，给雄性和雌性Sprague-Dawley（SD）大鼠口服2、4和8 g/kg剂量的GLA，持续28天。在急性毒性试验中，雄性和雌性小鼠均未出现死亡或临床变化。在亚急性毒性试验期间，治疗组和对照组之间的体重、食物摄入量、生化和血液学参数以及器官系数差异与GLA治疗无关。所得数据表明，在急性和亚急性毒性试验中，给雄性和雌性大鼠口服GLA没有显著毒性作用。
