Zhang Yi-Fei, Liang Shi-Shan, Wu Pei-Lin, Cai Yan-Liang, Lin Yue-Li, Wang Qing-Wen, Zhuang Xi-Bin, Chen Su-Qing
Department of Pediatrics, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2023 Jan 15;25(1):5-10. doi: 10.7499/j.issn.1008-8830.2207052.
To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection.
A retrospective analysis was performed on the medical data of 201 children with coronavirus disease 2019 (COVID-19) who were hospitalized and diagnosed with SARS-CoV-2 Omicron variant infection in Quanzhou First Hospital from March 14 to April 7, 2022. Among the 201 children, there were 34 children with asymptomatic infection and 167 with symptomatic infection. The two groups were compared in terms of clinical features, results of experimental examinations, and outcome.
Of all the 201 children, 161 (80.1%) had a history of exposure to COVID-19 patients and 132 (65.7%) had a history of COVID-19 vaccination. Among the 167 children with symptomatic infections, 151 had mild COVID-19 and 16 had common COVID-19, with no severe infection or death. Among the 101 children who underwent chest CT examination, 16 had ground glass changes and 20 had nodular or linear opacities. The mean time to nucleic acid clearance was (14±4) days for the 201 children with Omicron variant infection, and the symptomatic infection group had a significantly longer time than the asymptomatic infection group [(15±4) days vs (11±4) days, <0.05]. The group vaccinated with one or two doses of COVID-19 vaccine had a significantly higher positive rate of IgG than the group without vaccination (<0.05). The proportions of children with increased blood lymphocyte count in the symptomatic infection group was significantly lower than that in the asymptomatic infection group (<0.05). Compared with the asymptomatic infection group, the symptomatic infection group had significantly higher proportions of children with increased interleukin-6, increased fibrinogen, and increased D-dimer (<0.05).
Most of the children with Omicron variant infection have clinical symptoms, which are generally mild. The children with symptomatic infection are often accompanied by decreased or normal blood lymphocyte count and increased levels of interleukin-6, fibrinogen, and D-dimer, with a relatively long time to nucleic acid clearance. Some of them had ground glass changes on chest CT.
研究儿童感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）奥密克戎变异株的临床特征。
对2022年3月14日至4月7日在泉州市第一医院住院并确诊为SARS-CoV-2奥密克戎变异株感染的201例新型冠状病毒肺炎（COVID-19）患儿的病历资料进行回顾性分析。201例患儿中，无症状感染者34例，有症状感染者167例。比较两组的临床特征、实验室检查结果及转归。
201例患儿中，161例（80.1%）有新型冠状病毒肺炎患者接触史，132例（65.7%）有新型冠状病毒肺炎疫苗接种史。167例有症状感染者中，151例为轻型COVID-19，16例为普通型COVID-19，无重型感染及死亡病例。101例行胸部CT检查的患儿中，16例有磨玻璃样改变，20例有结节状或条索状阴影。201例奥密克戎变异株感染患儿核酸转阴时间平均为（14±4）天，有症状感染组较无症状感染组转阴时间明显延长[（15±4）天 vs （11±4）天，<0.05]。接种1剂或2剂新型冠状病毒肺炎疫苗组IgG阳性率明显高于未接种组（<0.05）。有症状感染组患儿血淋巴细胞计数升高的比例明显低于无症状感染组（<0.05）。与无症状感染组相比，有症状感染组患儿白细胞介素-6升高、纤维蛋白原升高及D-二聚体升高的比例明显更高（<0.05）。
奥密克戎变异株感染患儿多数有临床症状，一般症状较轻。有症状感染患儿常伴有血淋巴细胞计数降低或正常，白细胞介素-6、纤维蛋白原及D-二聚体水平升高，核酸转阴时间相对较长。部分患儿胸部CT有磨玻璃样改变。
